Literature DB >> 17168535

MLL core components give the green light to histone methylation.

Brendan D Crawford1, Jay L Hess.   

Abstract

Trimethylation of histone H3 Lys4 (H3K4) is associated with transcriptional activation. One of the chief effectors of H3K4 methylation is mixed-lineage leukemia 1 (MLL1), a gene that is disrupted by chromosomal translocation in acute leukemia and a master regulator of Hox and other genes. In a recent paper, core components of the human MLL histone methyltransferase (MT) complex were found to form a structural platform, with one component (WDR5) mediating association between the specific histone H3K4 substrate and the MT. This novel regulatory mechanism, which is conserved from yeast to human, is required for both methylation and downstream target gene transcription.

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Year:  2006        PMID： 17168535     DOI： 10.1021/cb600367v

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  17 in total

1.  HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

Authors:  Khairul I Ansari; Imran Hussain; Bishakha Shrestha; Sahba Kasiri; Subhrangsu S Mandal
Journal:  J Mol Biol       Date:  2011-06-12       Impact factor: 5.469

2.  A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.

Authors:  Ailing Li; Youyang Yang; Chong Gao; Jiayun Lu; Ha-Won Jeong; Bee H Liu; Ping Tang; Xiaopan Yao; Donna Neuberg; Gang Huang; Daniel G Tenen; Li Chai
Journal:  J Clin Invest       Date:  2013-09-24       Impact factor: 14.808

3.  Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression.

Authors:  Khairul I Ansari; Bishakha Shrestha; Imran Hussain; Sahba Kasiri; Subhrangsu S Mandal
Journal:  Biochemistry       Date:  2011-04-05       Impact factor: 3.162

4.  Ash2l interacts with Tbx1 and is required during early embryogenesis.

Authors:  Jason Z Stoller; Li Huang; Cheryl C Tan; Facan Huang; Diane D Zhou; Jifu Yang; Bruce D Gelb; Jonathan A Epstein
Journal:  Exp Biol Med (Maywood)       Date:  2010-05

Review 5.  Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond.

Authors:  Chun-Wei Chen; Scott A Armstrong
Journal:  Exp Hematol       Date:  2015-06-25       Impact factor: 3.084

6.  Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion.

Authors:  Jiakun Chen; Qicong Luo; Yuanyang Yuan; Xiaoli Huang; Wangyu Cai; Chao Li; Tongzhen Wei; Ludi Zhang; Meng Yang; Qingfeng Liu; Guodong Ye; Xing Dai; Boan Li
Journal:  Mol Cell Biol       Date:  2010-10-11       Impact factor: 4.272

7.  Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies.

Authors:  Manolis Gialitakis; Panagiota Arampatzi; Takis Makatounakis; Joseph Papamatheakis
Journal:  Mol Cell Biol       Date:  2010-02-01       Impact factor: 4.272

8.  Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation.

Authors:  Olivia I Koues; Ninad T Mehta; Agnieszka D Truax; R Kyle Dudley; Jeanne K Brooks; Susanna F Greer
Journal:  Epigenetics Chromatin       Date:  2010-02-04       Impact factor: 4.954

9.  Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo.

Authors:  Paromita Deb; Arunoday Bhan; Imran Hussain; Khairul I Ansari; Samara A Bobzean; Tej K Pandita; Linda I Perrotti; Subhrangsu S Mandal
Journal:  Gene       Date:  2016-05-13       Impact factor: 3.688

10.  Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.

Authors:  Shivani Garapaty; Chong-Feng Xu; Patrick Trojer; Muktar A Mahajan; Thomas A Neubert; Herbert H Samuels
Journal:  J Biol Chem       Date:  2009-01-08       Impact factor: 5.157
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