| Literature DB >> 17168462 |
O V Paiushina, E I Damaratskaia, E I Bueverova, T M Nikonova, N N Butorina, E A Molchanova, V I Starostin.
Abstract
The sensitivity of stromal stem cells (CFU-f) from rat bone marrow and fetal liver to the cytotoxic effect of 5-fluorouracil (5-FU) was compared in vivo and in vitro. Cells from both tissues demonstrated a similar resistance to 5-FU in vitro; however, stromal stem cells from fetal liver proved notably more sensitive to 5-FU compared to marrow CFU-f in vivo. Cells forming colonies of different size were identified in stem cell populations from both tissues. Cells giving rise to small colonies had a higher resistance to 5-FU both in vivo and in vitro.Entities:
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Year: 2006 PMID： 17168462
Source DB: PubMed Journal: Izv Akad Nauk Ser Biol ISSN： 1026-3470