OBJECTIVES: Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. METHODS: Among the members of the Korean MultiCenter Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. RESULTS: The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). CONCLUSIONS: This study provides no evidence for an association of the serum glucose level with gastric cancer.
OBJECTIVES:Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. METHODS: Among the members of the Korean MultiCenter Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using long-term stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. RESULTS: The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). CONCLUSIONS: This study provides no evidence for an association of the serum glucose level with gastric cancer.
Authors: Su Youn Nam; Bum Joon Park; Ji Hyung Nam; Kum Hei Ryu; Myeong-Cherl Kook; Jeongseon Kim; Won Kee Lee Journal: United European Gastroenterol J Date: 2018-12-12 Impact factor: 4.623
Authors: Jae Moon Yoon; Ki Young Son; Chun Sick Eom; Daniel Durrance; Sang Min Park Journal: World J Gastroenterol Date: 2013-02-14 Impact factor: 5.742
Authors: Danielle J Crawley; Lars Holmberg; Jennifer C Melvin; Massimo Loda; Simon Chowdhury; Sarah M Rudman; Mieke Van Hemelrijck Journal: BMC Cancer Date: 2014-12-19 Impact factor: 4.430
Authors: Bashir Dabo; Claudio Pelucchi; Matteo Rota; Harshonnati Jain; Paola Bertuccio; Rossella Bonzi; Domenico Palli; Monica Ferraroni; Zuo-Feng Zhang; Aurora Sanchez-Anguiano; Yen Thi-Hai Pham; Chi Thi-Du Tran; Anh Gia Pham; Guo-Pei Yu; Tin C Nguyen; Joshua Muscat; Shoichiro Tsugane; Akihisa Hidaka; Gerson S Hamada; David Zaridze; Dmitry Maximovitch; Manolis Kogevinas; Nerea Fernàndez de Larrea; Stefania Boccia; Roberta Pastorino; Robert C Kurtz; Areti Lagiou; Pagona Lagiou; Jesus Vioque; M Constanza Camargo; Maria Paula Curado; Nuno Lunet; Paolo Boffetta; Eva Negri; Carlo La Vecchia; Hung N Luu Journal: Eur J Cancer Prev Date: 2022-05-01 Impact factor: 2.164