PURPOSE: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to confirm the previous linkage peaks, a collection of DNA samples from 19 new Ashkenazi Jewish families were tested for linkage in a genome wide scan. METHODS: Families were ascertained from an Orthodox Ashkenazi Jewish community through mailings. Myopia was defined as equal to or greater than -1 diopter in both meridians in both eyes. The genome wide scan used markers from a modified Cooperative Human Linkage Center version 9 (402 markers). Parametric two-point linkage was calculated with FASTLINK while multipoint linkage was calculated with GENEHUNTER. RESULTS: The results for the 19 families demonstrated several regions of suggestive linkage on chromosomes 7, 1, 17, and 22. A combined analysis of the 19 families and 44 previously reported families demonstrated an increase in the LOD score to 4.73 for the chromosome 22 locus. CONCLUSIONS: Multiple chromosomal regions have exhibited some evidence of linkage to a myopia susceptibility gene in this Ashkenazi Jewish population. The strongest evidence of linkage to such a susceptibility gene in these data is on chromosome 22.
PURPOSE: A genome-wide scan was previously reported for myopia in Ashkenazi Jews. In order to confirm the previous linkage peaks, a collection of DNA samples from 19 new Ashkenazi Jewish families were tested for linkage in a genome wide scan. METHODS: Families were ascertained from an Orthodox Ashkenazi Jewish community through mailings. Myopia was defined as equal to or greater than -1 diopter in both meridians in both eyes. The genome wide scan used markers from a modified Cooperative Human Linkage Center version 9 (402 markers). Parametric two-point linkage was calculated with FASTLINK while multipoint linkage was calculated with GENEHUNTER. RESULTS: The results for the 19 families demonstrated several regions of suggestive linkage on chromosomes 7, 1, 17, and 22. A combined analysis of the 19 families and 44 previously reported families demonstrated an increase in the LOD score to 4.73 for the chromosome 22 locus. CONCLUSIONS: Multiple chromosomal regions have exhibited some evidence of linkage to a myopia susceptibility gene in this Ashkenazi Jewish population. The strongest evidence of linkage to such a susceptibility gene in these data is on chromosome 22.
Authors: Yi-Ju Li; Jeremy A Guggenheim; Anuradha Bulusu; Ravikanth Metlapally; Diana Abbott; Francois Malecaze; Patrick Calvas; Thomas Rosenberg; Sandrine Paget; Rosalind C Creer; George Kirov; Michael J Owen; Bei Zhao; Tristan White; David A Mackey; Terri L Young Journal: Invest Ophthalmol Vis Sci Date: 2009-03-25 Impact factor: 4.799
Authors: Robert Wojciechowski; Dwight Stambolian; Elise Ciner; Grace Ibay; Taura N Holmes; Joan E Bailey-Wilson Journal: Invest Ophthalmol Vis Sci Date: 2009-01-17 Impact factor: 4.799
Authors: Diana Abbott; Yi-Ju Li; Jeremy A Guggenheim; Ravikanth Metlapally; Francois Malecaze; Patrick Calvas; Thomas Rosenberg; Sandrine Paget; Tetyana Zayats; David A Mackey; Sheng Feng; Terri L Young Journal: Mol Vis Date: 2012-03-26 Impact factor: 2.367
Authors: Claire L Simpson; Robert Wojciechowski; Grace Ibay; Dwight Stambolian; Joan E Bailey-Wilson Journal: Mol Vis Date: 2011-06-17 Impact factor: 2.367
Authors: Sandrine Paget; Sophie Julia; Zulma G Vitezica; Vincent Soler; François Malecaze; Patrick Calvas Journal: Mol Vis Date: 2008-12-30 Impact factor: 2.367