| Literature DB >> 17166529 |
Bo Shao1, Hongzhu Guo, Yajun Cui, Min Ye, Jian Han, Dean Guo.
Abstract
Steroidal saponins, 1, 2, 3 and 4, were isolated from the BuOH extract of Smilax china L., along with 13 known compounds, 5-17. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses and chemical evidence. In the bioassay tests, all compounds showed inhibitory effects on cyclooxygenase-2 enzyme (COX-2) activities at final concentration of 10(-5) M, and only compound 5 showed an inhibitory effect on production of TNFalpha (tumor necrosis factor alpha) in murine peritoneal macrophages at the same concentration.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17166529 DOI： 10.1016/j.phytochem.2006.10.026
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072