Literature DB >> 17166487

Altered expression of Smad family members in injured motor neurons of rat.

Noriko Okuyama1, Sumiko Kiryu-Seo, Hiroshi Kiyama.   

Abstract

We examined changes in the expression of Smad family members, which transduce signals from TGF-beta superfamily ligands, following hypoglossal nerve injury. RT-PCR and in situ hybridization revealed that Smad1, 2, 3 and 4 mRNAs were significantly up-regulated in injured side, whereas Smad8 mRNA was down-regulated. Immunohistochemistry and Western blotting analysis confirmed the alterations of Smad1, 2 and 4 in injured neurons. These results suggest that the Smad signaling may be important for nerve regeneration.

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Year:  2006        PMID： 17166487     DOI： 10.1016/j.brainres.2006.11.019

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

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Review 2.  BMP signaling in axon regeneration.

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Review 8.  Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication.

Authors:  Nelson Osses; Juan P Henríquez
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Journal:  Cell Rep       Date:  2021-09-07       Impact factor: 9.423

Review 10.  What makes a RAG regeneration associated?

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Journal:  Front Mol Neurosci       Date:  2015-08-07       Impact factor: 5.639
  10 in total

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