Literature DB >> 17165700

A smart magnetic resonance contrast agent for selective copper sensing.

Emily L Que1, Christopher J Chang.   

Abstract

We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ over abundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.

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Year:  2006        PMID： 17165700     DOI： 10.1021/ja065264l

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  38 in total

Review 1.  Alternatives to gadolinium-based metal chelates for magnetic resonance imaging.

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2.  Activation of a PARACEST agent for MRI through selective outersphere interactions with phosphate diesters.

Authors:  Ching-Hui Huang; Jacob Hammell; S James Ratnakar; A Dean Sherry; Janet R Morrow
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Review 4.  Lanthanide probes for bioresponsive imaging.

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Journal:  Chem Rev       Date:  2013-12-13       Impact factor: 60.622

Review 5.  Application of metal coordination chemistry to explore and manipulate cell biology.

Authors:  Kathryn L Haas; Katherine J Franz
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

Review 6.  In situ imaging of metals in cells and tissues.

Authors:  Reagan McRae; Pritha Bagchi; S Sumalekshmy; Christoph J Fahrni
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

7.  Selective and sensitive detection of metal ions by plasmonic resonance energy transfer-based nanospectroscopy.

Authors:  Yeonho Choi; Younggeun Park; Taewook Kang; Luke P Lee
Journal:  Nat Nanotechnol       Date:  2009-09-06       Impact factor: 39.213

Review 8.  Environmentally responsive MRI contrast agents.

Authors:  Gemma-Louise Davies; Iris Kramberger; Jason J Davis
Journal:  Chem Commun (Camb)       Date:  2013-10-28       Impact factor: 6.222

9.  Towards extracellular Ca2+ sensing by MRI: synthesis and calcium-dependent 1H and 17O relaxation studies of two novel bismacrocyclic Gd3+ complexes.

Authors:  Kirti Dhingra; Petra Fousková; Goran Angelovski; Martin E Maier; Nikos K Logothetis; Eva Tóth
Journal:  J Biol Inorg Chem       Date:  2007-09-15       Impact factor: 3.358

Review 10.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622
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