[The role of manganese in the human organism].

Manganese is an essential element to be found in all tissues. It is needed for metabolism of amino acids, lipids, proteins and carbohydrates. Manganese takes part directly in the defense of red blood cells, in the metabolism of iron, in the synthesis of cholesterol of the membranes and oligosaccharides. Manganese plays significant role in the free radical defense system as MnSOD, which protects the endothelial and red blood cells and mitochondria from the damage caused by superoxide radicals. The metabolism of manganese (absorption, transport) is determined by the chemical form and quantity of manganese. Manganese deficiency is rare on healthy nutrition whereas manganese accumulation may develop as an occupational disease, preliminary.