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Literature DB >> 17165100

Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients.

Y J La¹, C L Wan, H Zhu, Y F Yang, Y S Chen, Y X Pan, G Y Feng, L He.

Abstract

This study aims to identify the effects of antipsychotics on plasma proteins, and on the proteins associated with schizophrenia. We applied proteomics technology to screen protein aberrations in Sprague-Dawley rats treated with antipsychotics and schizophrenic patients undergoing medication. ApoA-I was found significantly increased in the chlorpromazine-treated rats and decreased in the patients with treatment-resistant schizophrenia, which suggest that decreased levels of apoA-I might be associated with the pathology of schizophrenia and that chlorpromazine increases apoA-I levels as part of its therapeutic action.

Entities: Chemical Disease Gene Species

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Year: 2006 PMID： 17165100 DOI： 10.1007/s00702-006-0607-2

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

31 in total

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