Literature DB >> 17165004

Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.

Isao Matsushita1, Miwa Uzuki, Hiroaki Matsuno, Eiji Sugiyama, Tomoastu Kimura.   

Abstract

We report a 62-year-old man with rheumatoid arthritis (RA) who developed nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.

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Year:  2006        PMID： 17165004     DOI： 10.1007/s10165-006-0522-2

Source DB:  PubMed          Journal:  Mod Rheumatol        ISSN： 1439-7595            Impact factor:   3.023


  8 in total

Review 1.  Cutaneous nodules in patients with rheumatoid arthritis: a case report and review of literatures.

Authors:  Tadashi Nakamura; Syu-ichi Higashi; Kunihiko Tomoda; Michishi Tsukano; Ken-ichi Iyama
Journal:  Clin Rheumatol       Date:  2010-11-04       Impact factor: 2.980

2.  Clinicopathologic features of rheumatoid nodules: a retrospective analysis.

Authors:  Seongsik Bang; Yeseul Kim; Kiseok Jang; Seung Sam Paik; Su-Jin Shin
Journal:  Clin Rheumatol       Date:  2019-07-04       Impact factor: 2.980

3.  Downregulation of Tumour Necrosis Factor α Gene Expression in Peripheral Blood Mononuclear Cells Cultured in the Presence of Tofacitinib Prior to Therapy Is Associated with Clinical Remission in Patients with Rheumatoid Arthritis.

Authors:  Elena V Tchetina; Galina A Markova; Azamat M Satybaldyev; Aleksandr M Lila
Journal:  Curr Issues Mol Biol       Date:  2022-04-29       Impact factor: 2.976

4.  Mesenteric rheumatoid nodules masquerading as an intra-abdominal malignancy: a case report and review of the literature.

Authors:  Sumeer Thinda; James S Tomlinson
Journal:  World J Surg Oncol       Date:  2009-07-15       Impact factor: 2.754

5.  Granulomatous Cutaneous Drug Eruptions: A Systematic Review.

Authors:  Nidhi Shah; Monica Shah; Aaron M Drucker; Neil H Shear; Michael Ziv; Roni P Dodiuk-Gad
Journal:  Am J Clin Dermatol       Date:  2021-01       Impact factor: 7.403

6.  Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4⁺ T cells (Th17) cells in collagen-induced arthritis.

Authors:  Janette Furuzawa-Carballeda; Perla Macip-Rodríguez; Angeles S Galindo-Feria; David Cruz-Robles; Virgina Soto-Abraham; Sergio Escobar-Hernández; Diana Aguilar; Deshiré Alpizar-Rodríguez; Karen Férez-Blando; Luis Llorente
Journal:  Clin Dev Immunol       Date:  2011-10-19

7.  Multiple intracranial nodules associated with rheumatoid arthritis: case report.

Authors:  Mayu Takahashi; Junkoh Yamamoto; Masaru Idei; Yoshiteru Nakano; Yoshiteru Soejima; Takeshi Saito; Daisuke Akiba; Shigeru Nishizawa
Journal:  Neurol Med Chir (Tokyo)       Date:  2013-10-21       Impact factor: 1.742

8.  Rheumatoid factor positivity is associated with increased joint destruction and upregulation of matrix metalloproteinase 9 and cathepsin k gene expression in the peripheral blood in rheumatoid arthritic patients treated with methotrexate.

Authors:  Elena V Tchetina; Natalia V Demidova; Dmitry E Karateev; Eugeny L Nasonov
Journal:  Int J Rheumatol       Date:  2013-11-14
  8 in total

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