BACKGROUND: Obesity and diabetes are established risk factors for colorectal cancer but have mainly been assessed independently. There are few data about whether the metabolic syndrome, which refers to a clustering of cardiovascular disease risk factors thought to be related to insulin resistance, including obesity, type 2 diabetes, hyperlipidemia, and hypertension, is associated with colorectal cancer risk. METHODS: During and after the randomized trial of aspirin and beta-carotene, 22,071 healthy male physicians, initially ages 40 to 84 years, reported overweight (body mass index, >or=27 kg/m2), diabetes, elevated blood pressure (>or=130/85 mmHg or use of antihypertensive medication), hypercholesterolemia (>or=240 mg/dL or use of lipid-lowering medication), and occurrence of cancer on annual questionnaires. Adjusted relative risks (RR) and 95% confidence intervals (95% CI) for time-varying metabolic abnormalities and colorectal cancer were estimated using a multivariable proportional hazards model. RESULTS: During 369,966 person-years of follow-up (median, 19 years), 494 physicians developed colorectal cancer. With aging of the cohort, the prevalence of having two or more abnormalities increased from 13% to 35%. Overweight (RR, 1.4; 95% CI, 1.1-1.7) and diabetes (RR, 1.5; 95% CI, 1.1-2.0) were associated with increased risk for colorectal cancer, whereas elevated blood pressure (RR, 1.1; 95% CI, 0.9-1.3) and hypercholesterolemia (RR, 0.9; 95% CI, 0.7-1.1) were not. This model assessing metabolic abnormalities independently was more predictive for colorectal cancer than a model based on the number of abnormalities (each additional abnormality RR, 1.16; 95% CI, 1.05-1.29). CONCLUSIONS: Out of the markers of the metabolic syndrome assessed, overweight and diabetes are risk factors for colorectal cancer, whereas, in contrast to their role in cardiovascular disease, elevated blood pressure and hypercholesterolemia are not.
BACKGROUND:Obesity and diabetes are established risk factors for colorectal cancer but have mainly been assessed independently. There are few data about whether the metabolic syndrome, which refers to a clustering of cardiovascular disease risk factors thought to be related to insulin resistance, including obesity, type 2 diabetes, hyperlipidemia, and hypertension, is associated with colorectal cancer risk. METHODS: During and after the randomized trial of aspirin and beta-carotene, 22,071 healthy male physicians, initially ages 40 to 84 years, reported overweight (body mass index, >or=27 kg/m2), diabetes, elevated blood pressure (>or=130/85 mmHg or use of antihypertensive medication), hypercholesterolemia (>or=240 mg/dL or use of lipid-lowering medication), and occurrence of cancer on annual questionnaires. Adjusted relative risks (RR) and 95% confidence intervals (95% CI) for time-varying metabolic abnormalities and colorectal cancer were estimated using a multivariable proportional hazards model. RESULTS: During 369,966 person-years of follow-up (median, 19 years), 494 physicians developed colorectal cancer. With aging of the cohort, the prevalence of having two or more abnormalities increased from 13% to 35%. Overweight (RR, 1.4; 95% CI, 1.1-1.7) and diabetes (RR, 1.5; 95% CI, 1.1-2.0) were associated with increased risk for colorectal cancer, whereas elevated blood pressure (RR, 1.1; 95% CI, 0.9-1.3) and hypercholesterolemia (RR, 0.9; 95% CI, 0.7-1.1) were not. This model assessing metabolic abnormalities independently was more predictive for colorectal cancer than a model based on the number of abnormalities (each additional abnormality RR, 1.16; 95% CI, 1.05-1.29). CONCLUSIONS: Out of the markers of the metabolic syndrome assessed, overweight and diabetes are risk factors for colorectal cancer, whereas, in contrast to their role in cardiovascular disease, elevated blood pressure and hypercholesterolemia are not.
Authors: M L Slattery; Rachel Ballard-Barbash; Sandra Edwards; Bette J Caan; John D Potter Journal: Cancer Causes Control Date: 2003-02 Impact factor: 2.506
Authors: Paula M Brauer; Gail E McKeown-Eyssen; Vartouhi Jazmaji; Alexander G Logan; David F Andrews; David Jenkins; Norman Marcon; Fred Saibil; Lawrence Cohen; Hartley Stern; David Baron; Gordon Greenberg; Eleftherios Diamandis; Gary Kakis; William Singer; George Steiner Journal: Am J Epidemiol Date: 2002-10-15 Impact factor: 4.897
Authors: Laura A Colangelo; Susan M Gapstur; Peter H Gann; Alan R Dyer; Kiang Liu Journal: Cancer Epidemiol Biomarkers Prev Date: 2002-04 Impact factor: 4.254
Authors: Sharon H Saydah; Elizabeth A Platz; Nader Rifai; Michael N Pollak; Frederick L Brancati; Kathy J Helzlsouer Journal: Cancer Epidemiol Biomarkers Prev Date: 2003-05 Impact factor: 4.254
Authors: Xiaoyun Liang; Karen L Margolis; Michael Hendryx; Thomas E Rohan; Erik J Groessl; Cynthia A Thomson; Candyce H Kroenke; Michael S Simon; Dorothy Lane; Marcia Stefanick; Juhua Luo Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-02 Impact factor: 4.254
Authors: Hiroki Yuhara; Craig Steinmaus; Stephanie E Cohen; Douglas A Corley; Yoshihiro Tei; Patricia A Buffler Journal: Am J Gastroenterol Date: 2011-09-13 Impact factor: 10.864
Authors: Konstantinos K Tsilidis; Frederick L Brancati; Michael N Pollak; Nader Rifai; Sandra L Clipp; Judith Hoffman-Bolton; Kathy J Helzlsouer; Elizabeth A Platz Journal: Cancer Causes Control Date: 2009-09-23 Impact factor: 2.506