Literature DB >> 17164051

Impact of molecular profiling on clinical trial design for glioblastoma.

Arnab Chakravarti1, Erin Tyndall, Kamalakannan Palanichamy, Minesh Mehta, Kenneth Aldape, Jay Loeffler.   

Abstract

This review highlights the ways in which molecular and genetic profiling of malignant gliomas has led to intelligent clinical trial design. The review also highlights known resistance mechanisms to conventional therapies in malignant gliomas and potential strategies to overcome these mechanisms with the use of targeted therapy.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17164051     DOI： 10.1007/bf02951429

Source DB:  PubMed          Journal:  Curr Oncol Rep        ISSN： 1523-3790            Impact factor:   5.075


  37 in total

1.  Gene expression profiling of gliomas strongly predicts survival.

Authors:  William A Freije; F Edmundo Castro-Vargas; Zixing Fang; Steve Horvath; Timothy Cloughesy; Linda M Liau; Paul S Mischel; Stanley F Nelson
Journal:  Cancer Res       Date:  2004-09-15       Impact factor: 12.701

2.  Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells.

Authors:  F Ciardiello; R Bianco; V Damiano; G Fontanini; R Caputo; G Pomatico; S De Placido; A R Bianco; J Mendelsohn; G Tortora
Journal:  Clin Cancer Res       Date:  2000-09       Impact factor: 12.531

Review 3.  Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials.

Authors:  E S Newlands; M F Stevens; S R Wedge; R T Wheelhouse; C Brock
Journal:  Cancer Treat Rev       Date:  1997-01       Impact factor: 12.111

4.  Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death.

Authors:  P Dent; D B Reardon; J S Park; G Bowers; C Logsdon; K Valerie; R Schmidt-Ullrich
Journal:  Mol Biol Cell       Date:  1999-08       Impact factor: 4.138

Review 5.  Targeting epidermal growth factor receptor in lung cancer.

Authors:  José Baselga; Joan Albanell
Journal:  Curr Oncol Rep       Date:  2002-07       Impact factor: 5.075

6.  Epidermal growth factor receptor and labeling index are independent prognostic factors in glial tumor outcome.

Authors:  M C Etienne; J L Formento; C Lebrun-Frenay; J Gioanni; M Chatel; P Paquis; C Bernard; A Courdi; R J Bensadoun; J P Pignol; M Francoual; P Grellier; M Frenay; G Milano
Journal:  Clin Cancer Res       Date:  1998-10       Impact factor: 12.531

7.  Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.

Authors:  Heidi S Phillips; Samir Kharbanda; Ruihuan Chen; William F Forrest; Robert H Soriano; Thomas D Wu; Anjan Misra; Janice M Nigro; Howard Colman; Liliana Soroceanu; P Mickey Williams; Zora Modrusan; Burt G Feuerstein; Ken Aldape
Journal:  Cancer Cell       Date:  2006-03       Impact factor: 31.743

8.  The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.

Authors:  Arnab Chakravarti; Gary Zhai; Yoshiyuki Suzuki; Sormeh Sarkesh; Peter M Black; Alona Muzikansky; Jay S Loeffler
Journal:  J Clin Oncol       Date:  2004-05-15       Impact factor: 44.544

9.  Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

Authors:  Naoki Shinojima; Kenji Tada; Shoji Shiraishi; Takanori Kamiryo; Masato Kochi; Hideo Nakamura; Keishi Makino; Hideyuki Saya; Hirofumi Hirano; Jun-Ichi Kuratsu; Koji Oka; Yasuji Ishimaru; Yukitaka Ushio
Journal:  Cancer Res       Date:  2003-10-15       Impact factor: 12.701

10.  The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner.

Authors:  Arnab Chakravarti; Abhijit Chakladar; Meaghan A Delaney; Douglas E Latham; Jay S Loeffler
Journal:  Cancer Res       Date:  2002-08-01       Impact factor: 12.701
View more
  2 in total

Review 1.  Molecular profiling in glioblastoma: prelude to personalized treatment.

Authors:  Nikol Mladkova; Arnab Chakravarti
Journal:  Curr Oncol Rep       Date:  2009-01       Impact factor: 5.075

2.  Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers.

Authors:  Ovidiu C Andronesi; Konstantinos D Blekas; Dionyssios Mintzopoulos; Loukas Astrakas; Peter M Black; A Aria Tzika
Journal:  Int J Oncol       Date:  2008-11       Impact factor: 5.650
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.