| Literature DB >> 17163769 |
Abstract
Activation of Smad signaling pathways downstream of TGF-beta superfamily ligands via receptor-mediated Smad phosphorylation is well understood, but little is known about the phosphatases that turn off Smad activity. Now in Cell, Feng and colleagues (Lin, X., et al. (2006) Cell 125 , 915-928) report their discovery that PPM1A acts as a Smad phosphatase to terminate TGF-beta signaling.Entities:
Mesh：
Substances：
Year: 2006 PMID： 17163769 DOI： 10.1021/cb6002702
Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100