Literature DB >> 17163755

Drug discovery: here comes the worm.

Laurent Ségalat1.   

Abstract

Identification of bioactive molecules and their targets impedes the process of drug development. In a recent paper, a genetically tractable organism, the Caenorhabditis elegans worm, is shown to be a viable screening system in which the drug target and the pathway it activates can be readily identified.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17163755     DOI： 10.1021/cb600221m

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  7 in total

1.  Characterization of low molecular weight chemical fractions of dry bean (Phaseolus vulgaris) for bioactivity using Caenorhabditis elegans longevity and metabolite fingerprinting.

Authors:  Meghan M Mensack; Vanessa K Fitzgerald; Matthew R Lewis; Henry J Thompson
Journal:  J Agric Food Chem       Date:  2010-06-09       Impact factor: 5.279

2.  Using C. elegans for antimicrobial drug discovery.

Authors:  Athanasios Desalermos; Maged Muhammed; Justin Glavis-Bloom; Eleftherios Mylonakis
Journal:  Expert Opin Drug Discov       Date:  2011-06-01       Impact factor: 6.098

Review 3.  C. elegans in high-throughput drug discovery.

Authors:  Linda P O'Reilly; Cliff J Luke; David H Perlmutter; Gary A Silverman; Stephen C Pak
Journal:  Adv Drug Deliv Rev       Date:  2013-12-12       Impact factor: 15.470

4.  Control of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteria.

Authors:  Michelle S Teng; Paul Shadbolt; Andrew G Fraser; Gert Jansen; John McCafferty
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-24       Impact factor: 11.205

5.  Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans.

Authors:  Pilar González-Cabo; Arantxa Bolinches-Amorós; Juan Cabello; Sheila Ros; Sergio Moreno; Howard A Baylis; Francesc Palau; Rafael P Vázquez-Manrique
Journal:  J Biol Chem       Date:  2011-04-04       Impact factor: 5.157

Review 6.  Diversity, evolution and medical applications of insect antimicrobial peptides.

Authors:  Eleftherios Mylonakis; Lars Podsiadlowski; Maged Muhammed; Andreas Vilcinskas
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-05-26       Impact factor: 6.237

7.  Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of Caenorhabditis elegans and its functional response to drugs.

Authors:  Jennifer E Hewitt; Amelia K Pollard; Leila Lesanpezeshki; Colleen S Deane; Christopher J Gaffney; Timothy Etheridge; Nathaniel J Szewczyk; Siva A Vanapalli
Journal:  Dis Model Mech       Date:  2018-12-04       Impact factor: 5.758
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.