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Literature DB >> 17163724

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

Arezou A Ghazani¹, Jeongjin A Lee, Jesse Klostranec, Qing Xiang, Ralph S Dacosta, Brian C Wilson, Ming S Tsao, Warren C W Chan.

Abstract

We developed and validated a novel method for quantifying protein expression of cancer tumors in an accurate, sensitive, and high throughput format. This technique integrates quantum dots, tissue microarray, optical spectroscopy, and algorithm design for analysis of tumor biopsies. The integration of this method for tissue analysis in the clinic bears potential impact for improving the diagnosis and treatment of cancer.

Entities: Disease

Mesh：

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Year: 2006 PMID： 17163724 DOI： 10.1021/nl062111n

Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189

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Cited

19 in total

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4. Multicolor multicycle molecular profiling with quantum dots for single-cell analysis.

Authors: Pavel Zrazhevskiy; Lawrence D True; Xiaohu Gao
Journal: Nat Protoc Date: 2013-09-05 Impact factor: 13.491

5. Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots.

Authors: Jian Liu; Stephen K Lau; Vijay A Varma; Richard A Moffitt; Matthew Caldwell; Tao Liu; Andrew N Young; John A Petros; Adeboye O Osunkoya; Tracey Krogstad; Brian Leyland-Jones; May D Wang; Shuming Nie
Journal: ACS Nano Date: 2010-05-25 Impact factor: 15.881

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

1. Quantum dots for molecular pathology: their time has arrived.

2. Quantitative in situ detection of phosphoproteins in fixed tissues using quantum dot technology.

3. Nanoparticles: Emerging carriers for drug delivery.

4. Multicolor multicycle molecular profiling with quantum dots for single-cell analysis.

5. Molecular mapping of tumor heterogeneity on clinical tissue specimens with multiplexed quantum dots.

6. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry.

7. Multiplexed detection and characterization of rare tumor cells in Hodgkin's lymphoma with multicolor quantum dots.

Review 8. Semiconductor quantum dots for bioimaging and biodiagnostic applications.

Review 9. Convergence of biomarkers, bioinformatics and nanotechnology for individualized cancer treatment.

10. Nanoparticles for Improving Cancer Diagnosis.