Robert Philibert1. 1. University of lowa, lowa City, IA 52242-1000, USA. robertphilibert@uiowa.edu
Abstract
BACKGROUND: It is generally acknowledged that the vast majority of serious mental disorders have significant genetic contributions that manifest complex inheritance patterns. Despite this, few gene polymorphisms have been unambiguously identified as risk factors for behavioral illness and the mechanisms through which these select polymorphisms affect human behavior is completely unclear. One of the major reasons for this lack of progress is the phenomenon of gene-environment (GxE) interactions. METHODS: We review prior evidence of GxE interactions for major depressive disorder (MDD) in the Iowa Adoption Studies. RESULTS: The results demonstrate the usefulness of these cohorts to direct G effects for MDD. CONCLUSIONS: We conclude that further use of the adoption paradigm will generate critical insight into the effects of candidate genes for a variety of complex human behavioral illnesses.
BACKGROUND: It is generally acknowledged that the vast majority of serious mental disorders have significant genetic contributions that manifest complex inheritance patterns. Despite this, few gene polymorphisms have been unambiguously identified as risk factors for behavioral illness and the mechanisms through which these select polymorphisms affect human behavior is completely unclear. One of the major reasons for this lack of progress is the phenomenon of gene-environment (GxE) interactions. METHODS: We review prior evidence of GxE interactions for major depressive disorder (MDD) in the Iowa Adoption Studies. RESULTS: The results demonstrate the usefulness of these cohorts to direct G effects for MDD. CONCLUSIONS: We conclude that further use of the adoption paradigm will generate critical insight into the effects of candidate genes for a variety of complex human behavioral illnesses.
Authors: Robert A Philibert; Steven R H Beach; Tracy D Gunter; Alexandre A Todorov; Gene H Brody; Meeshanthini Vijayendran; Lilly Elliott; Nancy Hollenbeck; Daniel Russell; Carolyn Cutrona Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2011-05-11 Impact factor: 3.568
Authors: Allan M Andersen; Robert A Philibert; Fredrick X Gibbons; Ronald L Simons; Jeffrey Long Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-06-14 Impact factor: 3.568
Authors: Robert A Philibert; Pamela Wernett; Jeff Plume; Hans Packer; Gene H Brody; Steven R H Beach Journal: Biol Psychol Date: 2011-05-07 Impact factor: 3.251
Authors: Steven R H Beach; Gene H Brody; Alexandre A Todorov; Tracy D Gunter; Robert A Philibert Journal: Psychosom Med Date: 2010-10-14 Impact factor: 4.312
Authors: Robert A Philibert; Harinder Sandhu; Nancy Hollenbeck; Tracy Gunter; William Adams; Anup Madan Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-07-05 Impact factor: 3.568
Authors: Robert A Philibert; Jeffrey M Plume; Frederick X Gibbons; Gene H Brody; Steven R H Beach Journal: Front Genet Date: 2012-04-10 Impact factor: 4.599
Authors: Meeshanthini Vijayendran; Steven R H Beach; Jeffrey M Plume; Gene H Brody; Robert A Philibert Journal: Front Psychiatry Date: 2012-06-13 Impact factor: 4.157
Authors: A Erhardt; N Akula; J Schumacher; D Czamara; N Karbalai; B Müller-Myhsok; O Mors; A Borglum; A S Kristensen; D P D Woldbye; P Koefoed; E Eriksson; E Maron; A Metspalu; J Nurnberger; R A Philibert; J Kennedy; K Domschke; A Reif; J Deckert; T Otowa; Y Kawamura; H Kaiya; Y Okazaki; H Tanii; K Tokunaga; T Sasaki; J P A Ioannidis; F J McMahon; E B Binder Journal: Transl Psychiatry Date: 2012-09-04 Impact factor: 6.222