Literature DB >> 17162587

Synthesis and antiviral properties of aza-analogues of acyclovir.

Mariola Koszytkowska-Stawińska1, Katarzyna Kaleta, Wojciech Sas, Erik De Clercq.   

Abstract

Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.

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Year:  2007        PMID: 17162587     DOI: 10.1080/15257770601052281

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN: 1525-7770            Impact factor:   1.381


  2 in total

1.  Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.

Authors:  Mariola Koszytkowska-Stawińska; Erik De Clercq; Jan Balzarini
Journal:  Bioorg Med Chem       Date:  2009-05-03       Impact factor: 3.641

2.  Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.

Authors:  Rafał Gawin; Erik De Clercq; Lieve Naesens; Mariola Koszytkowska-Stawińska
Journal:  Bioorg Med Chem       Date:  2008-08-26       Impact factor: 3.641

  2 in total

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