| Literature DB >> 17161664 |
Stephen Flatman1, Imtiaz Alam, Jeffery Gerard, Nesredin Mussa.
Abstract
The application of appropriate analytical methods is an essential requirement for the purification of therapeutic antibodies. A range of analytical methods need to be employed to effectively determine the purity, identity, integrity and activity of these important class of pharmaceuticals. These include notably electrophoresis, high performance liquid chromatography and immunoassays. Regulatory and industry demands in recent years have brought the need for improvements and many have been successfully implemented. This article reviews the current analytical methods applied to support the purification of monoclonal antibodies.Mesh：
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Year: 2006 PMID： 17161664 DOI： 10.1016/j.jchromb.2006.11.018
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205