Literature DB >> 17161634

Re-employment of developmental transcription factors in adult heart disease.

Toru Oka1, Jian Xu, Jeffery D Molkentin.   

Abstract

A finite number of transcription factors constitute a combinatorial code that orchestrates cardiac development and the specification and differentiation of myocytes. Many, if not all of these same transcription factors are re-employed in the adult heart in response to disease stimuli that promote hypertrophic enlargement and/or dilated cardiomyopathy, as part of the so-called "fetal gene program". This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development.

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Year:  2006        PMID： 17161634      PMCID： PMC1855184          DOI： 10.1016/j.semcdb.2006.11.012

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  222 in total

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Authors:  Q Liang; R J Wiese; O F Bueno; Y S Dai; B E Markham; J D Molkentin
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7.  Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line.

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Journal:  Circ Res       Date:  1998-07-13       Impact factor: 17.367
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  78 in total

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Journal:  Mol Cell Biol       Date:  2011-09-19       Impact factor: 4.272

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Review 4.  Electrical and mechanical stimulation of cardiac cells and tissue constructs.

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5.  The delta isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload.

Authors:  Johannes Backs; Thea Backs; Stefan Neef; Michael M Kreusser; Lorenz H Lehmann; David M Patrick; Chad E Grueter; Xiaoxia Qi; James A Richardson; Joseph A Hill; Hugo A Katus; Rhonda Bassel-Duby; Lars S Maier; Eric N Olson
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6.  Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.

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9.  Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.

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Review 10.  Cardiomyocyte-specific inactivation of thyroid hormone in pathologic ventricular hypertrophy: an adaptative response or part of the problem?

Authors:  Christine J Pol; Alice Muller; Warner S Simonides
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