Edward W Randell1, Maria Mathews2, Veeresh Gadag2, Hongwei Zhang3, Guang Sun3. 1. Division of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada; Division of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada; Health Care Corporation of St. John's, St. John's, Nfld A1B 3V6, Canada. Electronic address: erandell@mun.ca. 2. Division of Community Health, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada. 3. Division of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Nfld A1B 3V6, Canada.
Abstract
UNLABELLED: Serum magnesium (SMg) has been reported to negatively correlate with an atherogenic lipid profile in individuals with diabetes mellitus (DM) and metabolic syndrome. This study examines whether the relationships between SMg levels and biochemical and anthropometric risk factors for these conditions are also present in the general adult population. DESIGN AND METHODS: Biochemical parameters and anthropometric variables were assessed in 1318 healthy adult subjects recruited from the Newfoundland population. RESULTS: SMg positively correlated with age, and serum phosphate, calcium, albumin, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride levels. SMg negatively correlated with HOMA-beta and percent body fat measured by DEXA. On sub-grouping subjects according to sex, menopausal status or after excluding subjects with DM, only a significant correlation of SMg with albumin, calcium, phosphate, and total cholesterol was common to all. Stepwise linear regression analysis revealed albumin, phosphate, age, total cholesterol, glucose, and body mass index as independent predictors of SMg levels. CONCLUSIONS: These results indicate that SMg levels positively correlate with total cholesterol and possibly all lipoproteins in a large adult study population which suggests that variation of SMg with serum lipid levels may be different in healthy individuals compared with those with DM. We speculate on a possible binding interaction.
UNLABELLED: Serum magnesium (SMg) has been reported to negatively correlate with an atherogenic lipid profile in individuals with diabetes mellitus (DM) and metabolic syndrome. This study examines whether the relationships between SMg levels and biochemical and anthropometric risk factors for these conditions are also present in the general adult population. DESIGN AND METHODS: Biochemical parameters and anthropometric variables were assessed in 1318 healthy adult subjects recruited from the Newfoundland population. RESULTS:SMg positively correlated with age, and serum phosphate, calcium, albumin, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride levels. SMg negatively correlated with HOMA-beta and percent body fat measured by DEXA. On sub-grouping subjects according to sex, menopausal status or after excluding subjects with DM, only a significant correlation of SMg with albumin, calcium, phosphate, and total cholesterol was common to all. Stepwise linear regression analysis revealed albumin, phosphate, age, total cholesterol, glucose, and body mass index as independent predictors of SMg levels. CONCLUSIONS: These results indicate that SMg levels positively correlate with total cholesterol and possibly all lipoproteins in a large adult study population which suggests that variation of SMg with serum lipid levels may be different in healthy individuals compared with those with DM. We speculate on a possible binding interaction.
Authors: Rebecca B Costello; Ronald J Elin; Andrea Rosanoff; Taylor C Wallace; Fernando Guerrero-Romero; Adela Hruby; Pamela L Lutsey; Forrest H Nielsen; Martha Rodriguez-Moran; Yiqing Song; Linda V Van Horn Journal: Adv Nutr Date: 2016-11-15 Impact factor: 8.701
Authors: Kristian K Green; Jennifer L Shea; Sudesh Vasdev; Edward Randell; Wayne Gulliver; Guang Sun Journal: Clin Med Insights Endocrinol Diabetes Date: 2010-03-31