BACKGROUND: Obsessive-compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive-compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. METHODS: This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. RESULTS: A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. CONCLUSIONS: In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span.
BACKGROUND:Obsessive-compulsive disorder (OCD) has a broadly diverse clinical expression that may reflect etiologic heterogeneity. Several adult studies have identified consistent symptom dimensions of OCD. The purpose of this study was to conduct an exploratory principal components analysis of obsessive-compulsive (OC) symptoms in children and adolescents with OCD to identify improved phenotypes for future studies. METHODS: This study examined lifetime occurrence of OC symptoms included in the 13 symptom categories of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Principal components analysis with promax rotation was performed on 231 children and adolescents with OCD and compared with results of similar adult studies. RESULTS: A four-factor solution emerged explaining 59.8% of symptom variance characterized by 1) symmetry/ordering/repeating/checking; 2) contamination/cleaning/aggressive/somatic; 3) hoarding; and 4) sexual/religious symptoms. All factors included core symptoms that have been consistently observed in adult studies of OCD. CONCLUSIONS: In children and adolescents, OCD is a multidimensional disorder. Symptom dimensions are predominantly congruent with those described in similar studies of adults with OCD, suggesting fairly consistent covariation of OCD symptoms through the developmental course. Future work is required to understand changes in specific symptom dimensions observed across the life span.
Authors: Margaret A Richter; Danilo R de Jesus; Sylco Hoppenbrouwers; Melissa Daigle; Jasna Deluce; Lakshmi N Ravindran; Paul B Fitzgerald; Zafiris J Daskalakis Journal: Neuropsychopharmacology Date: 2011-12-14 Impact factor: 7.853
Authors: Marian Tanofsky-Kraff; Lien Goossens; Kamryn T Eddy; Rebecca Ringham; Andrea Goldschmidt; Susan Z Yanovski; Caroline Braet; Marsha D Marcus; Denise E Wilfley; Cara Olsen; Jack A Yanovski Journal: J Consult Clin Psychol Date: 2007-12
Authors: Michelle Rozenman; Tara Peris; R Lindsey Bergman; Susanna Chang; Joseph O'Neill; James T McCracken; John Piacentini Journal: Child Psychiatry Hum Dev Date: 2017-02
Authors: Hilga Katerberg; Kevin L Delucchi; S Evelyn Stewart; Christine Lochner; Damiaan A J P Denys; Denise E Stack; J Michael Andresen; J E Grant; Suck W Kim; Kyle A Williams; Johan A den Boer; Anton J L M van Balkom; Johannes H Smit; Patricia van Oppen; Annemiek Polman; Michael A Jenike; Dan J Stein; Carol A Mathews; Danielle C Cath Journal: Behav Genet Date: 2010-04-02 Impact factor: 2.805