Literature DB >> 1716112

Cytokeratin expression in the epithelia of the adult human cochlea.

L J Bauwens1, J C DeGroot, F C Ramaekers, J E Veldman, E H Huizing.   

Abstract

Epithelia can be characterized by the specific expression pattern of their cytokeratin components. Therefore, we investigated the immunohistochemical expression of different cytokeratin subunits in frozen sections of chemically fixed, non-decalcified, adult human cochleas. The organ of Corti and the marginal cells of the stria vascularis showed reactivity for cytokeratin subunits 8, 18 and 19, whereas the other cochlear epithelia in addition expressed cytokeratin 7. The expression of cytokeratins 7, 8, 18 and 19 by the epithelia of the adult human cochlea is typical of "simple" epithelia. The deviant cytokeratin pattern of the organ of Corti and marginal cells of the stria vascularis may well reflect their differences in functional state and/or differentiation as compared to the other cochlear epithelia.

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Year:  1991        PMID： 1716112     DOI： 10.1007/bf00176758

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  19 in total

1.  Progress in temporal bone histopathology. III. An improved technique for immunohistochemical investigation of the adult human inner ear.

Authors:  L J Bauwens; J E Veldman; E H Huizing
Journal:  Acta Otolaryngol Suppl       Date:  1990

2.  Regional variations in the expression of cytokeratin proteins in the adult human cochlea.

Authors:  M Anniko; W Arnold; L E Thornell; I Virtanen; F C Ramaekers; C R Pfaltz
Journal:  Eur Arch Otorhinolaryngol       Date:  1990       Impact factor: 2.503

Review 3.  Intermediate filaments: conformity and diversity of expression and structure.

Authors:  P M Steinert; D A Parry
Journal:  Annu Rev Cell Biol       Date:  1985

4.  Coexpression of intermediate filament polypeptides in human fetal and adult tissues.

Authors:  G N Van Muijen; D J Ruiter; S O Warnaar
Journal:  Lab Invest       Date:  1987-10       Impact factor: 5.662

5.  Distribution of cytokeratin polypeptides in human transitional cell carcinomas, with special emphasis on changing expression patterns during tumor progression.

Authors:  H E Schaafsma; F C Ramaekers; G N van Muijen; E B Lane; I M Leigh; H Robben; A Huijsmans; E C Ooms; D J Ruiter
Journal:  Am J Pathol       Date:  1990-02       Impact factor: 4.307

6.  Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues.

Authors:  W W Franke; D L Schiller; R Moll; S Winter; E Schmid; I Engelbrecht; H Denk; R Krepler; B Platzer
Journal:  J Mol Biol       Date:  1981-12-25       Impact factor: 5.469

7.  Basal cell-specific and hyperproliferation-related keratins in human breast cancer.

Authors:  R H Wetzels; H J Kuijpers; E B Lane; I M Leigh; S M Troyanovsky; R Holland; U J van Haelst; F C Ramaekers
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

8.  Expression of intermediate filament proteins in the adult human cochlea.

Authors:  L J Bauwens; J E Veldman; H Bouman; F C Ramaekers; E H Huizing
Journal:  Ann Otol Rhinol Laryngol       Date:  1991-03       Impact factor: 1.547

Review 9.  Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview.

Authors:  F C Ramaekers; J J Puts; O Moesker; A Kant; A Huysmans; D Haag; P H Jap; C J Herman; G P Vooijs
Journal:  Histochem J       Date:  1983-07

10.  Tissue distribution of keratin 7 as monitored by a monoclonal antibody.

Authors:  F Ramaekers; A Huysmans; G Schaart; O Moesker; P Vooijs
Journal:  Exp Cell Res       Date:  1987-05       Impact factor: 3.905
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  3 in total

1.  Differential immunohistochemical detection of cytokeratins and vimentin in the surgically removed human endolymphatic duct and sac.

Authors:  L J Bauwens; J C De Groot; F C Ramaekers; F Linthicum; J E Veldman; E H Huizing
Journal:  Eur Arch Otorhinolaryngol       Date:  1991       Impact factor: 2.503

2.  Hair cell differentiation in chick cochlear epithelium after aminoglycoside toxicity: in vivo and in vitro observations.

Authors:  J S Stone; S G Leaño; L P Baker; E W Rubel
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

3.  Generation of human inner ear prosensory-like cells via epithelial-to-mesenchymal transition.

Authors:  Zhengqing Hu; Xuemei Luo; Lei Zhang; Fengqing Lu; Fengping Dong; Edwin Monsell; Hui Jiang
Journal:  Regen Med       Date:  2012-09       Impact factor: 3.806
  3 in total

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