BACKGROUND: The purpose of this study was to create a model that predicts which breast cancer patients will have sentinel lymph node (SLN)-only metastasis. METHODS: SLN-positive breast cancer patients (N = 1,253) were analyzed. Multivariate analysis was performed to identify factors predicting SLN-only disease; a prediction rule was created. RESULTS: Median tumor size was 2 cm. The median number of SLNs removed was 2; the median number of positive SLNs was 1. Multivariate analysis found tumor size, number of positive SLN, and proportion of SLN positive were significant predictors of SLN-only disease (P < .001). A prediction rule with 1 point being given for >1 positive SLN, 1 point for >50% of SLN positive, and up to 4 points for tumor size (T1a = 1, T1b or T1c = 2, T2 = 3, and T3 = 4) was established. Ninety-five percent of patients with 1 point had SLN-only disease (P < .0001). CONCLUSION: An integer-based model may predict SLN-only disease and may be useful in determining whether completion axillary lymph node dissection is required.
BACKGROUND: The purpose of this study was to create a model that predicts which breast cancerpatients will have sentinel lymph node (SLN)-only metastasis. METHODS: SLN-positive breast cancerpatients (N = 1,253) were analyzed. Multivariate analysis was performed to identify factors predicting SLN-only disease; a prediction rule was created. RESULTS: Median tumor size was 2 cm. The median number of SLNs removed was 2; the median number of positive SLNs was 1. Multivariate analysis found tumor size, number of positive SLN, and proportion of SLN positive were significant predictors of SLN-only disease (P < .001). A prediction rule with 1 point being given for >1 positive SLN, 1 point for >50% of SLN positive, and up to 4 points for tumor size (T1a = 1, T1b or T1c = 2, T2 = 3, and T3 = 4) was established. Ninety-five percent of patients with 1 point had SLN-only disease (P < .0001). CONCLUSION: An integer-based model may predict SLN-only disease and may be useful in determining whether completion axillary lymph node dissection is required.
Authors: Raquel F D van la Parra; Petronella G M Peer; Wilfred K de Roos; Miranda F Ernst; Johannes H W de Wilt; Koop Bosscha Journal: World J Surg Date: 2014-05 Impact factor: 3.352
Authors: Gábor Cserni; Rita Bori; Róbert Maráz; Marjut H K Leidenius; Tuomo J Meretoja; Paivi S Heikkila; Peter Regitnig; Gero Luschin-Ebengreuth; Janez Zgajnar; Andraz Perhavec; Barbara Gazic; György Lázár; Tibor Takács; András Vörös; Riccardo A Audisio Journal: Pathol Oncol Res Date: 2012-07-14 Impact factor: 3.201
Authors: Anna V Britto; André A Schenka; Natália G Moraes-Schenka; Marcelo Alvarenga; Júlia Y Shinzato; José Vassallo; Laura S Ward Journal: BMC Cancer Date: 2009-04-08 Impact factor: 4.430