BACKGROUND: Neoadjuvant chemoradiation is increasingly used for rectal cancer, with resection typically performed 6 weeks after completion of radiotherapy. We observed in our practice that further delay after radiotherapy led to increased downsizing. We performed this retrospective analysis to evaluate the safety of this approach. METHODS: A retrospective review was performed of 48 patients with distal or mid-rectal cancer who were operated on 8 weeks or less after chemoradiation ended (group 1, n = 16), and more than 8 weeks later (group 2, n = 32). We looked at the effect of delaying surgery on intraoperative blood loss, operative and hospital duration, postoperative complications, readmissions, and mortality. RESULTS: The median interval between radiation and operation was 7 weeks in group 1 and 11 weeks in group 2. There was no significant difference between the 2 groups in terms of intraoperative blood loss, postoperative complications, or readmissions. Length of operation and length of stay were slightly longer for group 2. CONCLUSIONS: Delaying surgery after neoadjuvant treatment appears safe, with morbidity and mortality similar to that seen with surgery performed less than 8 weeks after chemoradiation.
BACKGROUND: Neoadjuvant chemoradiation is increasingly used for rectal cancer, with resection typically performed 6 weeks after completion of radiotherapy. We observed in our practice that further delay after radiotherapy led to increased downsizing. We performed this retrospective analysis to evaluate the safety of this approach. METHODS: A retrospective review was performed of 48 patients with distal or mid-rectal cancer who were operated on 8 weeks or less after chemoradiation ended (group 1, n = 16), and more than 8 weeks later (group 2, n = 32). We looked at the effect of delaying surgery on intraoperative blood loss, operative and hospital duration, postoperative complications, readmissions, and mortality. RESULTS: The median interval between radiation and operation was 7 weeks in group 1 and 11 weeks in group 2. There was no significant difference between the 2 groups in terms of intraoperative blood loss, postoperative complications, or readmissions. Length of operation and length of stay were slightly longer for group 2. CONCLUSIONS: Delaying surgery after neoadjuvant treatment appears safe, with morbidity and mortality similar to that seen with surgery performed less than 8 weeks after chemoradiation.
Authors: Felipe A Calvo; Virginia Morillo; Marcos Santos; Javier Serrano; Marina Gomez-Espí; Marcos Rodriguez; Emilio Del Vale; Jose Luis Gracia-Sabrido; Carlos Ferrer; Claudio Sole Journal: J Cancer Res Clin Oncol Date: 2014-06-01 Impact factor: 4.553
Authors: Jae Y Kim; Arlene M Correa; Ara A Vaporciyan; Jack A Roth; Reza J Mehran; Garrett L Walsh; David C Rice; Jaffer A Ajani; Dipen M Maru; Manoop S Bhutani; James Welsh; Edith M Marom; Stephen G Swisher; Wayne L Hofstetter Journal: Ann Thorac Surg Date: 2011-10-01 Impact factor: 4.330
Authors: Luiz Felipe de Campos-Lobato; Daniel P Geisler; Andre da Luz Moreira; Luca Stocchi; David Dietz; Matthew F Kalady Journal: J Gastrointest Surg Date: 2010-12-08 Impact factor: 3.452
Authors: Annefleur E M Berkel; Dankert P Woutersen; Job van der Palen; Joost M Klaase Journal: J Gastrointest Surg Date: 2014-06-18 Impact factor: 3.452
Authors: K Horisberger; R D Hofheinz; P Palma; A K Volkert; S Rothenhoefer; F Wenz; A Hochhaus; S Post; F Willeke Journal: Int J Colorectal Dis Date: 2007-12-11 Impact factor: 2.571