BACKGROUND: This study was designed to determine whether or not older trauma patients on clopidogrel have an increased risk of morbidity and mortality. METHODS: A retrospective review was performed on all trauma patients > or =50 years of age between January 1, 2002, and August 31, 2005. The charts of those patients who had documented preinjury use of clopidogrel were further reviewed. A control group of patients with no history of clopidogrel use was matched for age, sex, mechanism of injury, and injury severity score. RESULTS: During this time period, there were 1,020 trauma patients > or =50 years of age admitted, 43 of which had documented preinjury clopidogrel use (P). A higher percentage of patients in the P group underwent cranial surgery, had episodes of rebleeds, and required transfusions of blood products than in the control group. The mortality and length of stay were comparable in both groups. CONCLUSION: This study indicates that the preinjury use of clopidogrel may cause significant morbidity in patients with closed-head injuries. Further studies are needed to suggest specific treatment modalities.
BACKGROUND: This study was designed to determine whether or not older traumapatients on clopidogrel have an increased risk of morbidity and mortality. METHODS: A retrospective review was performed on all traumapatients > or =50 years of age between January 1, 2002, and August 31, 2005. The charts of those patients who had documented preinjury use of clopidogrel were further reviewed. A control group of patients with no history of clopidogrel use was matched for age, sex, mechanism of injury, and injury severity score. RESULTS: During this time period, there were 1,020 traumapatients > or =50 years of age admitted, 43 of which had documented preinjury clopidogrel use (P). A higher percentage of patients in the P group underwent cranial surgery, had episodes of rebleeds, and required transfusions of blood products than in the control group. The mortality and length of stay were comparable in both groups. CONCLUSION: This study indicates that the preinjury use of clopidogrel may cause significant morbidity in patients with closed-head injuries. Further studies are needed to suggest specific treatment modalities.
Authors: Daniel K Nishijima; Samuel Gaona; Trent Waechter; Ric Maloney; Troy Bair; Adam Blitz; Andrew R Elms; Roel D Farrales; Calvin Howard; James Montoya; Jeneita M Bell; Victor C Coronado; David E Sugerman; Dustin W Ballard; Kevin E Mackey; David R Vinson; James F Holmes Journal: Prehosp Emerg Care Date: 2016-09-16 Impact factor: 3.077
Authors: Daniel K Nishijima; Steven R Offerman; Dustin W Ballard; David R Vinson; Uli K Chettipally; Adina S Rauchwerger; Mary E Reed; James F Holmes Journal: Ann Emerg Med Date: 2012-06 Impact factor: 5.721
Authors: Daniel K Nishijima; Samuel D Gaona; Trent Waechter; Ric Maloney; Adam Blitz; Andrew R Elms; Roel D Farrales; James Montoya; Troy Bair; Calvin Howard; Megan Gilbert; Renee P Trajano; Kaela M Hatchel; Mark Faul; Jeneita M Bell; Victor C Coronado; David R Vinson; Dustin W Ballard; Daniel J Tancredi; Hernando Garzon; Kevin E Mackey; Kiarash Shahlaie; James F Holmes Journal: J Neurotrauma Date: 2018-02-09 Impact factor: 5.269
Authors: Daniel K Nishijima; Steven R Offerman; Dustin W Ballard; David R Vinson; Uli K Chettipally; Adina S Rauchwerger; Mary E Reed; James F Holmes Journal: Acad Emerg Med Date: 2013-02 Impact factor: 3.451