Literature DB >> 17159123

High seroprevalence of Epstein-Barr virus in children with multiple sclerosis.

D Pohl1, B Krone, K Rostasy, E Kahler, E Brunner, M Lehnert, H-J Wagner, J Gärtner, F Hanefeld.   

Abstract

We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.

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Year:  2006        PMID： 17159123     DOI： 10.1212/01.wnl.0000247665.94088.8d

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  61 in total

Review 1.  99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Epstein-Barr virus and multiple sclerosis: epidemiological evidence.

Authors:  A Ascherio; K L Munger
Journal:  Clin Exp Immunol       Date:  2010-04       Impact factor: 4.330

Review 2.  Infectious Mononucleosis.

Authors:  Samantha K Dunmire; Kristin A Hogquist; Henry H Balfour
Journal:  Curr Top Microbiol Immunol       Date:  2015       Impact factor: 4.291

Review 3.  Epstein-barr virus: environmental trigger of multiple sclerosis?

Authors:  Jan D Lünemann; Thomas Kamradt; Roland Martin; Christian Münz
Journal:  J Virol       Date:  2007-04-25       Impact factor: 5.103

Review 4.  Pediatric multiple sclerosis.

Authors:  E Ann Yeh; Tanuja Chitnis; Lauren Krupp; Jayne Ness; Dorothée Chabas; Nancy Kuntz; Emmanuelle Waubant
Journal:  Nat Rev Neurol       Date:  2009-10-13       Impact factor: 42.937

Review 5.  Therapies for multiple sclerosis: considerations in the pediatric patient.

Authors:  Brenda Banwell; Amit Bar-Or; Gavin Giovannoni; Russell C Dale; Marc Tardieu
Journal:  Nat Rev Neurol       Date:  2011-01-11       Impact factor: 42.937

Review 6.  [Multiple sclerosis and Epstein-Barr virus : new developments and perspectives].

Authors:  K Ruprecht
Journal:  Nervenarzt       Date:  2008-04       Impact factor: 1.214

Review 7.  Advances in pediatric neurovirology.

Authors:  John R Crawford
Journal:  Curr Neurol Neurosci Rep       Date:  2010-03       Impact factor: 5.081

8.  Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis.

Authors:  M P Pender; P A Csurhes; A Lenarczyk; C M M Pfluger; S R Burrows
Journal:  J Neurol Neurosurg Psychiatry       Date:  2008-11-17       Impact factor: 10.154

Review 9.  Is the risk of multiple sclerosis related to the 'biography' of the immune system?

Authors:  Bernd Krone; Frank Oeffner; John M Grange
Journal:  J Neurol       Date:  2009-03-01       Impact factor: 4.849

Review 10.  Potential triggers of MS.

Authors:  Jane E Libbey; Robert S Fujinami
Journal:  Results Probl Cell Differ       Date:  2010
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