Literature DB >> 17158906

Rapid clearance of Lyme disease spirochetes lacking OspC from skin.

Kit Tilly1, Aaron Bestor, Mollie W Jewett, Patricia Rosa.   

Abstract

We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission.

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Year:  2006        PMID： 17158906      PMCID： PMC1828573          DOI： 10.1128/IAI.01725-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  23 in total

1.  Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice.

Authors:  Emir Hodzic; Sunlian Feng; Kim J Freet; Stephen W Barthold
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

2.  Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice.

Authors:  T G Schwan; J Piesman
Journal:  J Clin Microbiol       Date:  2000-01       Impact factor: 5.948

3.  Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain background.

Authors:  Abdallah F Elias; Philip E Stewart; Dorothee Grimm; Melissa J Caimano; Christian H Eggers; Kit Tilly; James L Bono; Darrin R Akins; Justin D Radolf; Tom G Schwan; Patricia Rosa
Journal:  Infect Immun       Date:  2002-04       Impact factor: 3.441

4.  New antibiotic resistance cassettes suitable for genetic studies in Borrelia burgdorferi.

Authors:  Abdallah F Elias; James L Bono; John J Kupko; Philip E Stewart; Jonathan G Krum; Patricia A Rosa
Journal:  J Mol Microbiol Biotechnol       Date:  2003

5.  Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin.

Authors:  Timothy R Crother; Cheryl I Champion; Julian P Whitelegge; Rodrigo Aguilera; Xiao-Yang Wu; David R Blanco; James N Miller; Michael A Lovett
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

6.  Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals.

Authors:  Dorothee Grimm; Kit Tilly; Rebecca Byram; Philip E Stewart; Jonathan G Krum; Dawn M Bueschel; Tom G Schwan; Paul F Policastro; Abdallah F Elias; Patricia A Rosa
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-17       Impact factor: 11.205

Review 7.  Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi.

Authors:  T G Schwan
Journal:  Biochem Soc Trans       Date:  2003-02       Impact factor: 5.407

8.  The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi.

Authors:  Rebecca Byram; Philip E Stewart; Patricia Rosa
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490

9.  Immunochemical and immunological analysis of European Borrelia burgdorferi strains.

Authors:  B Wilske; V Preac-Mursic; G Schierz; K V Busch
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1986-12

10.  An immune evasion mechanism for spirochetal persistence in Lyme borreliosis.

Authors:  Fang Ting Liang; Mary B Jacobs; Lisa C Bowers; Mario T Philipp
Journal:  J Exp Med       Date:  2002-02-18       Impact factor: 14.307
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  69 in total

1.  Requirements for Borrelia burgdorferi plasmid maintenance.

Authors:  Kit Tilly; Claire Checroun; Patricia A Rosa
Journal:  Plasmid       Date:  2012-01-24       Impact factor: 3.466

2.  The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete.

Authors:  Melisha R Kenedy; Darrin R Akins
Journal:  Infect Immun       Date:  2011-01-31       Impact factor: 3.441

3.  Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Authors:  Jerilyn R Izac; Andrew C Camire; Christopher G Earnhart; Monica E Embers; Rebecca A Funk; Edward B Breitschwerdt; Richard T Marconi
Journal:  Vaccine       Date:  2019-03-25       Impact factor: 3.641

4.  Enhanced Protective Immunogenicity of Homodimeric Borrelia burgdorferi Outer Surface Protein C.

Authors:  Diane G Edmondson; Sabitha Prabhakaran; Steven J Norris; Amy J Ullmann; Joe Piesman; Marc Dolan; Christian Probst; Christiane Radzimski; Winfried Stöcker; Lars Komorowski
Journal:  Clin Vaccine Immunol       Date:  2017-01-05

5.  Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice.

Authors:  Kevin S Brandt; Toni G Patton; Anna S Allard; Melissa J Caimano; Justin D Radolf; Robert D Gilmore
Journal:  Clin Vaccine Immunol       Date:  2014-02-05

6.  Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi.

Authors:  Kit Tilly; Aaron Bestor; Patricia A Rosa
Journal:  Infect Immun       Date:  2016-04-22       Impact factor: 3.441

7.  Changes in bacterial growth rate govern expression of the Borrelia burgdorferi OspC and Erp infection-associated surface proteins.

Authors:  Brandon L Jutras; Alicia M Chenail; Brian Stevenson
Journal:  J Bacteriol       Date:  2012-12-07       Impact factor: 3.490

Review 8.  Biology of infection with Borrelia burgdorferi.

Authors:  Kit Tilly; Patricia A Rosa; Philip E Stewart
Journal:  Infect Dis Clin North Am       Date:  2008-06       Impact factor: 5.982

9.  Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences.

Authors:  Qilong Xu; Kristy McShan; Fang Ting Liang
Journal:  Mol Microbiol       Date:  2008-04-28       Impact factor: 3.501

10.  The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete.

Authors:  Jenny A Hyde; Dana K Shaw; Roger Smith Iii; Jerome P Trzeciakowski; Jon T Skare
Journal:  Mol Microbiol       Date:  2009-11-10       Impact factor: 3.501
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