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Literature DB >> 17158890

Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.

Heloisa D'Avila¹, Patrícia E Almeida, Natália R Roque, Hugo C Castro-Faria-Neto, Patrícia T Bozza.

Abstract

An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

Entities: Chemical Disease Gene Species

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Year: 2006 PMID： 17158890 PMCID： PMC1828599 DOI： 10.1128/IAI.01326-06

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

27 in total

1. Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice.

Authors: J Kirman; Z Zakaria; K McCoy; B Delahunt; G Le Gros
Journal: Infect Immun Date: 2000-05 Impact factor: 3.441

Review 2. Toll-like receptors and innate immunity.

Authors: R Medzhitov
Journal: Nat Rev Immunol Date: 2001-11 Impact factor: 53.106

3. Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils.

Authors: C Bandeira-Melo; M Phoofolo; P F Weller
Journal: J Biol Chem Date: 2001-03-26 Impact factor: 5.157

4. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.

Authors: Y Bulut; E Faure; L Thomas; O Equils; M Arditi
Journal: J Immunol Date: 2001-07-15 Impact factor: 5.422

Review 5. Leukocyte lipid bodies regulation and function: contribution to allergy and host defense.

Authors: Patricia T Bozza; Rossana C N Melo; Christianne Bandeira-Melo
Journal: Pharmacol Ther Date: 2006-09-01 Impact factor: 12.310

6. Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.

Authors: T K Means; B W Jones; A B Schromm; B A Shurtleff; J A Smith; J Keane; D T Golenbock; S N Vogel; M J Fenton
Journal: J Immunol Date: 2001-03-15 Impact factor: 5.422

7. LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin.

Authors: C Penido; H C Castro-Faria-Neto; A Vieira-de-Abreu; R T Figueiredo; A Pelled; M A Martins; P J Jose; T J Williams; P T Bozza
Journal: Am J Respir Cell Mol Biol Date: 2001-12 Impact factor: 6.914

8. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.

Authors: Ian Sabroe; Elizabeth C Jones; Lynne R Usher; Moira K B Whyte; Steven K Dower
Journal: J Immunol Date: 2002-05-01 Impact factor: 5.422

9. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism.

Authors: Patrícia Pacheco; Fernando A Bozza; Rachel N Gomes; Marcelo Bozza; Peter F Weller; Hugo C Castro-Faria-Neto; Patrícia T Bozza
Journal: J Immunol Date: 2002-12-01 Impact factor: 5.422

10. Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach.

Authors: S Ragno; M Romano; S Howell; D J Pappin; P J Jenner; M J Colston
Journal: Immunology Date: 2001-09 Impact factor: 7.397

10 in total

Review 1. The dynamic roles of intracellular lipid droplets: from archaea to mammals.

Authors: Denis J Murphy
Journal: Protoplasma Date: 2011-10-15 Impact factor: 3.356

2. Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis.

Authors: Camila Silva Guerra; Roger Magno Macedo Silva; Luís Otávio Pereira Carvalho; Kátia da Silva Calabrese; Patrícia Torres Bozza; Suzana Côrte-Real
Journal: Int J Exp Pathol Date: 2010-10 Impact factor: 1.925

Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy.

1. Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice.

Review 2. Toll-like receptors and innate immunity.

3. Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils.

4. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.

Review 5. Leukocyte lipid bodies regulation and function: contribution to allergy and host defense.

6. Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.

7. LPS induces eosinophil migration via CCR3 signaling through a mechanism independent of RANTES and Eotaxin.

8. Toll-like receptor (TLR)2 and TLR4 in human peripheral blood granulocytes: a critical role for monocytes in leukocyte lipopolysaccharide responses.

9. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism.

10. Changes in gene expression in macrophages infected with Mycobacterium tuberculosis: a combined transcriptomic and proteomic approach.

Review 1. The dynamic roles of intracellular lipid droplets: from archaea to mammals.

2. Histopathological analysis of initial cellular response in TLR-2 deficient mice experimentally infected by Leishmania (L.) amazonensis.

3. Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells.

Review 4. Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity?

Review 5. The regulatory role of eosinophils in viral, bacterial, and fungal infections.

Review 6. Leukocyte lipid bodies - Biogenesis and functions in inflammation.

7. Eosinophil deficiency compromises lung defense against Aspergillus fumigatus.

Review 8. Lipid Droplet, a Key Player in Host-Parasite Interactions.

9. Molecular analysis of non-specific protection against murine malaria induced by BCG vaccination.

Review 10. Eosinophil Polymorphonuclear Leukocytes in TB: What We Know so Far.