Literature DB >> 17158672

Amino acid residues required for maturation, cell uptake, and processing of translation inhibitor microcin C.

Teymur Kazakov1, Anastasia Metlitskaya, Konstantin Severinov.   

Abstract

Microcin C (McC), a peptide-nucleotide Trojan horse antibiotic, targets aspartyl-tRNA synthetase. We present the results of a systematic mutational study of the 7-amino-acid ribosomally synthesized peptide moiety of McC. Our results define amino acid positions important for McC maturation and cell uptake and processing and open the way for creation of more potent McC-based inhibitors.

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Year:  2006        PMID： 17158672      PMCID： PMC1855700          DOI： 10.1128/JB.01609-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  9 in total

Review 1.  The regulation of microcin B, C and J operons.

Authors:  Felipe Moreno; José Eduardo Gónzalez-Pastor; Maria Rosario Baquero; Daniel Bravo
Journal:  Biochimie       Date:  2002 May-Jun       Impact factor: 4.079

Review 2.  Focus on modified microcins: structural features and mechanisms of action.

Authors:  Delphine Destoumieux-Garzón; Jean Peduzzi; Sylvie Rebuffat
Journal:  Biochimie       Date:  2002 May-Jun       Impact factor: 4.079

3.  Major biocontrol of plant tumors targets tRNA synthetase.

Authors:  John S Reader; Phillip T Ordoukhanian; Jung-Gun Kim; Valerie de Crécy-Lagard; Ingyu Hwang; Stephen Farrand; Paul Schimmel
Journal:  Science       Date:  2005-09-02       Impact factor: 47.728

4.  The smallest known gene.

Authors:  J E González-Pastor; J L San Millán; F Moreno
Journal:  Nature       Date:  1994-05-26       Impact factor: 49.962

5.  Aspartyl-tRNA synthetase is the target of peptide nucleotide antibiotic Microcin C.

Authors:  Anastasia Metlitskaya; Teymur Kazakov; Aigar Kommer; Olga Pavlova; Mette Praetorius-Ibba; Michael Ibba; Igor Krasheninnikov; Vyacheslav Kolb; Inessa Khmel; Konstantin Severinov
Journal:  J Biol Chem       Date:  2006-03-30       Impact factor: 5.157

6.  Microcin C51 plasmid genes: possible source of horizontal gene transfer.

Authors:  Dmitri E Fomenko; Anastazia Z Metlitskaya; Jean Péduzzi; Christophe Goulard; Genrikh S Katrukha; Leonid V Gening; Sylvie Rebuffat; Inessa A Khmel
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

7.  Microcin plasmids: a group of extrachromosomal elements coding for low-molecular-weight antibiotics in Escherichia coli.

Authors:  F Baquero; D Bouanchaud; M C Martinez-Perez; C Fernandez
Journal:  J Bacteriol       Date:  1978-08       Impact factor: 3.490

8.  Chemical structure and translation inhibition studies of the antibiotic microcin C7.

Authors:  J I Guijarro; J E González-Pastor; F Baleux; J L San Millán; M A Castilla; M Rico; F Moreno; M Delepierre
Journal:  J Biol Chem       Date:  1995-10-06       Impact factor: 5.157

9.  Structure of microcin C51, a new antibiotic with a broad spectrum of activity.

Authors:  A Z Metlitskaya; G S Katrukha; A S Shashkov; D A Zaitsev; T A Egorov; I A Khmel
Journal:  FEBS Lett       Date:  1995-01-09       Impact factor: 4.124
  9 in total
  8 in total

1.  Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.

Authors:  Teymur Kazakov; Gaston H Vondenhoff; Kirill A Datsenko; Maria Novikova; Anastasia Metlitskaya; Barry L Wanner; Konstantin Severinov
Journal:  J Bacteriol       Date:  2008-01-25       Impact factor: 3.490

2.  Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.

Authors:  Gaston H M Vondenhoff; Bart Blanchaert; Sophie Geboers; Teymur Kazakov; Kirill A Datsenko; Barry L Wanner; Jef Rozenski; Konstantin Severinov; Arthur Van Aerschot
Journal:  J Bacteriol       Date:  2011-05-20       Impact factor: 3.490

3.  MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic.

Authors:  Maria Novikova; Teymur Kazakov; Gaston H Vondenhoff; Ekaterina Semenova; Jef Rozenski; Anastasija Metlytskaya; Inna Zukher; Anton Tikhonov; Arthur Van Aerschot; Konstantin Severinov
Journal:  J Biol Chem       Date:  2010-02-16       Impact factor: 5.157

4.  Enzymatic Synthesis and Functional Characterization of Bioactive Microcin C-Like Compounds with Altered Peptide Sequence and Length.

Authors:  Olga Bantysh; Marina Serebryakova; Inna Zukher; Alexey Kulikovsky; Darya Tsibulskaya; Svetlana Dubiley; Konstantin Severinov
Journal:  J Bacteriol       Date:  2015-07-20       Impact factor: 3.490

Review 5.  Microcin C: biosynthesis and mechanisms of bacterial resistance.

Authors:  Konstantin Severinov; Satish K Nair
Journal:  Future Microbiol       Date:  2012-02       Impact factor: 3.165

6.  Synthetic microcin C analogs targeting different aminoacyl-tRNA synthetases.

Authors:  Pieter Van de Vijver; Gaston H M Vondenhoff; Teymur S Kazakov; Ekaterina Semenova; Konstantin Kuznedelov; Anastasia Metlitskaya; Arthur Van Aerschot; Konstantin Severinov
Journal:  J Bacteriol       Date:  2009-08-14       Impact factor: 3.490

7.  Maturation of the translation inhibitor microcin C.

Authors:  Anastasia Metlitskaya; Teymur Kazakov; Gaston H Vondenhoff; Maria Novikova; Alexander Shashkov; Timofei Zatsepin; Ekaterina Semenova; Natalia Zaitseva; Vasily Ramensky; Arthur Van Aerschot; Konstantin Severinov
Journal:  J Bacteriol       Date:  2009-01-23       Impact factor: 3.490

8.  How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.

Authors:  Catherine A Regni; Rebecca F Roush; Darcie J Miller; Amanda Nourse; Christopher T Walsh; Brenda A Schulman
Journal:  EMBO J       Date:  2009-06-04       Impact factor: 11.598
  8 in total

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