Literature DB >> 171582

X-ray analysis of glucagon and its relationship to receptor binding.

K Sasaki, S Dockerill, D A Adamiak, I J Tickle, T Blundell.   

Abstract

X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 171582     DOI： 10.1038/257751a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  38 in total

Review 1.  Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors.

Authors:  Kuntal Pal; Karsten Melcher; H Eric Xu
Journal:  Acta Pharmacol Sin       Date:  2012-01-23       Impact factor: 6.150

2.  Optimization of the native glucagon sequence for medicinal purposes.

Authors:  Joseph R Chabenne; Maria A DiMarchi; Vasily M Gelfanov; Richard D DiMarchi
Journal:  J Diabetes Sci Technol       Date:  2010-11-01

Review 3.  The nature of amyloid-like glucagon fibrils.

Authors:  Jesper Søndergaard Pedersen
Journal:  J Diabetes Sci Technol       Date:  2010-11-01

Review 4.  Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins.

Authors:  Yingxue Li; Mark R Lefever; Dhanasekaran Muthu; Jean M Bidlack; Edward J Bilsky; Robin Polt
Journal:  Future Med Chem       Date:  2012-02       Impact factor: 3.808

5.  Design of Potent and Proteolytically Stable Oxyntomodulin Analogs.

Authors:  Avinash Muppidi; Huafei Zou; Peng Yu Yang; Elizabeth Chao; Lance Sherwood; Vanessa Nunez; Ashley K Woods; Peter G Schultz; Qing Lin; Weijun Shen
Journal:  ACS Chem Biol       Date:  2016-01-04       Impact factor: 5.100

6.  X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.

Authors:  T L Blundell; J E Pitts; I J Tickle; S P Wood; C W Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

7.  Peptide conformation in gas phase probed by collision-induced dissociation and its correlation to conformation in condensed phases.

Authors:  Zhongqi Zhang; Joseph Bordas-Nagy
Journal:  J Am Soc Mass Spectrom       Date:  2006-04-03       Impact factor: 3.109

8.  Early stages of amyloid fibril formation studied by liquid-state NMR: the peptide hormone glucagon.

Authors:  Anna Sigrid Pii Svane; Kasper Jahn; Taru Deva; Anders Malmendal; Daniel Erik Otzen; Jens Dittmer; Niels Chr Nielsen
Journal:  Biophys J       Date:  2008-03-13       Impact factor: 4.033

9.  Studies on the interaction of glucagon with phospholipids.

Authors:  R M Epand; J M Sturtevant
Journal:  Biophys J       Date:  1982-01       Impact factor: 4.033

10.  Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor.

Authors:  Christoph Parthier; Martin Kleinschmidt; Piotr Neumann; Rainer Rudolph; Susanne Manhart; Dagmar Schlenzig; Jörg Fanghänel; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth; Milton T Stubbs
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-21       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.