BACKGROUND: Methadone ingestion may cause delayed coma and require naloxone infusion. Few studies exist regarding the time development of symptoms following methadone overdose in adults. METHODS: After a brief training period, reviewers who were blinded to the purpose of the study completed a standardized data collection sheet. Two consecutive years of poison center patient encounters were reviewed. Age, outcomes, coingestions, vital signs, clinical manifestations, hospital admissions, and mortality were abstracted. Data were analyzed using descriptive statistics. The first reviewer was designated to extract the data. The second reviewer conducted a review of 20% of all the charts for a kappa value to be calculated. RESULTS: In total, 44 cases of isolated methadone overdose in patients older than 18 years were identified. A mean age of 32.5 (18-58) years and a mean presumed ingestion of 106 mg of methadone was calculated. Of the 44 patients, 32 received naloxone for symptoms consistent with opiate toxicity. All symptoms occurred within 9 hours of methadone ingestion, with a mean symptom onset of 3.2 hours. All patients had resolution of symptoms within 24 hours. No deaths were recorded. The kappa score for interreviewer reliability was 0.69, with a 95% confidence interval of 0.58 to 0.73. LIMITATIONS: This was a retrospective study that was limited by patient history. CONCLUSION: Acute methadone toxicity typically results in symptoms within 9 hours of ingestion.
BACKGROUND:Methadone ingestion may cause delayed coma and require naloxone infusion. Few studies exist regarding the time development of symptoms following methadoneoverdose in adults. METHODS: After a brief training period, reviewers who were blinded to the purpose of the study completed a standardized data collection sheet. Two consecutive years of poison center patient encounters were reviewed. Age, outcomes, coingestions, vital signs, clinical manifestations, hospital admissions, and mortality were abstracted. Data were analyzed using descriptive statistics. The first reviewer was designated to extract the data. The second reviewer conducted a review of 20% of all the charts for a kappa value to be calculated. RESULTS: In total, 44 cases of isolated methadoneoverdose in patients older than 18 years were identified. A mean age of 32.5 (18-58) years and a mean presumed ingestion of 106 mg of methadone was calculated. Of the 44 patients, 32 received naloxone for symptoms consistent with opiate toxicity. All symptoms occurred within 9 hours of methadone ingestion, with a mean symptom onset of 3.2 hours. All patients had resolution of symptoms within 24 hours. No deaths were recorded. The kappa score for interreviewer reliability was 0.69, with a 95% confidence interval of 0.58 to 0.73. LIMITATIONS: This was a retrospective study that was limited by patient history. CONCLUSION: Acute methadonetoxicity typically results in symptoms within 9 hours of ingestion.
Authors: Yasamin Atighi; Nastaran Eizadi-Mood; Marjan Mansourian; Amin Zamani; Ali Saffaei; Ali Mohammad Sabzghabaee Journal: J Res Pharm Pract Date: 2018 Oct-Dec
Authors: Nastaran Eizadi-Mood; Ahmad Yaraghi; Zahra Sharifian; Awat Feizi; Mahrang Hedaiaty; Ali Mohammad Sabzghabaee Journal: Mater Sociomed Date: 2015-08