BACKGROUND: Early vitamin supplementation is given routinely to infants in many countries, but it is unclear whether this affects the risk of allergic diseases. OBJECTIVES: We sought to study the association between early-life supplementation of vitamins A and D in water-soluble form or in peanut oil and allergic diseases up to 4 years of age. METHODS: A prospective birth cohort of 4089 newborn infants was followed for 4 years using parental questionnaires repeatedly to collect information on exposure and health. At 4 years, the response rate was 90%, and allergen-specific IgE levels to food and airborne allergens were measured in 2614 of the participating children. RESULTS: Vitamins A and D were given to 98% of the children in infancy, and vitamins based in peanut oil dominated (90%). Children supplemented with vitamins A and D in water-soluble form during the first year of life had an almost 2-fold increased risk of asthma (adjusted odds ratio [OD], 2.18; 95% CI, 1.45-3.28), food hypersensitivity (adjusted OR, 1.89; 95% CI, 1.33-2.65), and sensitization to common food and airborne allergens (adjusted OR, 1.88; 95% CI, 1.34-2.64) at age 4 years compared with those receiving vitamins in peanut oil. No increased risk of IgE antibodies to peanut was seen in children receiving vitamins in peanut oil. CONCLUSION: Supplementation of vitamins A and D in water-soluble form seems to increase the risk of allergic disease up to the age of 4 years compared with supplementation with the same vitamins given in peanut oil. CLINICAL IMPLICATIONS: Vitamins A and D in oil does not seem to increase the risk of allergic disease during childhood.
BACKGROUND: Early vitamin supplementation is given routinely to infants in many countries, but it is unclear whether this affects the risk of allergic diseases. OBJECTIVES: We sought to study the association between early-life supplementation of vitamins A and D in water-soluble form or in peanut oil and allergic diseases up to 4 years of age. METHODS: A prospective birth cohort of 4089 newborn infants was followed for 4 years using parental questionnaires repeatedly to collect information on exposure and health. At 4 years, the response rate was 90%, and allergen-specific IgE levels to food and airborne allergens were measured in 2614 of the participating children. RESULTS: Vitamins A and D were given to 98% of the children in infancy, and vitamins based in peanut oil dominated (90%). Children supplemented with vitamins A and D in water-soluble form during the first year of life had an almost 2-fold increased risk of asthma (adjusted odds ratio [OD], 2.18; 95% CI, 1.45-3.28), food hypersensitivity (adjusted OR, 1.89; 95% CI, 1.33-2.65), and sensitization to common food and airborne allergens (adjusted OR, 1.88; 95% CI, 1.34-2.64) at age 4 years compared with those receiving vitamins in peanut oil. No increased risk of IgE antibodies to peanut was seen in children receiving vitamins in peanut oil. CONCLUSION: Supplementation of vitamins A and D in water-soluble form seems to increase the risk of allergic disease up to the age of 4 years compared with supplementation with the same vitamins given in peanut oil. CLINICAL IMPLICATIONS: Vitamins A and D in oil does not seem to increase the risk of allergic disease during childhood.
Authors: Alberto Arnedo-Pena; Luis García-Marcos; Jorge Fuertes Fernández-Espinar; Alberto Bercedo-Sanz; Ines Aguinaga-Ontoso; Carlos González-Díaz; Ignacio Carvajal-Urueña; Rosa Busquet-Monge; Maria Morales Suárez-Varela; Nagore García de Andoin; Juan Batlles-Garrido; Alfredo Blanco-Quirós; Angel López-Silvarrey Varela; Gloria García-Hernández Journal: Int J Biometeorol Date: 2010-08-28 Impact factor: 3.787
Authors: Janet Rothers; Anne L Wright; Debra A Stern; Marilyn Halonen; Carlos A Camargo Journal: J Allergy Clin Immunol Date: 2011-08-19 Impact factor: 10.793
Authors: Victor Matheu; Karin Berggård; Yvelise Barrios; Ysamar Barrios; Maria-Rosa Arnau; Jose M Zubeldia; Maria L Baeza; Ove Back; Shohreh Issazadeh-Navikas Journal: Nutr Metab (Lond) Date: 2009-10-23 Impact factor: 4.169