Ulrich H M Spandau1, Jost B Jonas. 1. Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. Ulrich.Spandu@augen.ma.uni-heidelberg.de
Abstract
PURPOSE: To report on the development of retinal pigment epithelium tears after intravitreal injections of bevacizumab as treatment of exudative age-related macular degeneration (AMD). DESIGN: Interventional case series. METHODS: The study included 63 patients who received an intravitreal injection of 1.5 mg bevacizumab as treatment of a detachment of the retinal pigment epithelium attributable to AMD and who had a follow-up of at least two months. RESULTS: Four patients (6%) developed a tear of the retinal pigment epithelium in the parafoveal region. Compared with the baseline value, visual acuity at the end of follow-up remained stable in three patients and declined in the fourth patient. CONCLUSIONS: Intravitreal injections of bevacizumab may be followed by a tear of the retinal pigment epithelium in eyes with exudative AMD and a retinal pigment epithelium detachment.
PURPOSE: To report on the development of retinal pigment epithelium tears after intravitreal injections of bevacizumab as treatment of exudative age-related macular degeneration (AMD). DESIGN: Interventional case series. METHODS: The study included 63 patients who received an intravitreal injection of 1.5 mg bevacizumab as treatment of a detachment of the retinal pigment epithelium attributable to AMD and who had a follow-up of at least two months. RESULTS: Four patients (6%) developed a tear of the retinal pigment epithelium in the parafoveal region. Compared with the baseline value, visual acuity at the end of follow-up remained stable in three patients and declined in the fourth patient. CONCLUSIONS: Intravitreal injections of bevacizumab may be followed by a tear of the retinal pigment epithelium in eyes with exudative AMD and a retinal pigment epithelium detachment.
Authors: M Gutfleisch; B Heimes; M Schumacher; M Dietzel; A Lommatzsch; A Bird; D Pauleikhoff Journal: Eye (Lond) Date: 2011-06-24 Impact factor: 3.775
Authors: Pia E Leon; Sandro Saviano; Andrea Zanei; Marco R Pastore; Elvira Guaglione; Alessandro Mangogna; Daniele Tognetto Journal: Int J Ophthalmol Date: 2014-08-18 Impact factor: 1.779