Literature DB >> 17157402

Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism.

Naohisa Tsujino1, Yasushi Nakatani, Yoshinari Seki, Akane Nakasato, Michiko Nakamura, Michiya Sugawara, Hideho Arita.   

Abstract

Several clinical reports have indicated that autistic patients often show disturbance of the circadian rhythm, which may be related to dysfunction of the serotonergic system in the brain. Using rats exposed prenatally to valproic acid (VPA) as an animal model of autism, we examined locomotor activity and feeding under a reversed 12-h light/dark cycle, and found disturbance of the circadian rhythm characterized by frequent arousal during the light/sleep phase. In addition, measurement of brain serotonin (5-HT) level using in vivo microdialysis showed that the brain 5-HT level in VPA-exposed rats was significantly higher than that in control rats. These results suggest that a higher brain 5-HT level might be responsible for the irregular sleep/awake rhythm in autism.

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Year:  2006        PMID： 17157402     DOI： 10.1016/j.neures.2006.10.018

Source DB:  PubMed          Journal:  Neurosci Res        ISSN： 0168-0102            Impact factor:   3.304


  22 in total

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4.  In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.

Authors:  Danielle M Cusmano; Jessica A Mong
Journal:  Sleep       Date:  2014-09-01       Impact factor: 5.849

5.  Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats.

Authors:  T Sandhya; J Sowjanya; B Veeresh
Journal:  Neurochem Res       Date:  2012-02-10       Impact factor: 3.996

Review 6.  The serotonin system in autism spectrum disorder: From biomarker to animal models.

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Review 7.  Serotonin-related rodent models of early-life exposure relevant for neurodevelopmental vulnerability to psychiatric disorders.

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8.  The intense world theory - a unifying theory of the neurobiology of autism.

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Review 9.  Sleep Disorders in Children With Autism Spectrum Disorder: Insights From Animal Models, Especially Non-human Primate Model.

Authors:  Shufei Feng; Haoyu Huang; Na Wang; Yuanyuan Wei; Yun Liu; Dongdong Qin
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10.  Genetic and pharmacological manipulations of the serotonergic system in early life: neurodevelopmental underpinnings of autism-related behavior.

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