BACKGROUND: Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively. METHODS: Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic interactions between cocaine and a putative functional polymorphism in DbetaH (-1021C-->T) were assessed. RESULTS: VAS self-ratings showed significant or trend-level interactions of genotype and time during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia over time than either CT or CC individuals. Interactions were significant at all doses in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished genotypic groups. CONCLUSIONS: Results indicate that individuals homozygous for the 'very low-activity' T allele at DbetaH -1021C-->T show an increased propensity to paranoia over time during cocaine self-administration.
BACKGROUND: Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively. METHODS: Visual analog scale (VAS) ratings of paranoia were obtained in 31 cocaine users during three cocaine self-administration sessions (8, 16, and 32 mg/70 kg). Pharmacogenetic interactions between cocaine and a putative functional polymorphism in DbetaH (-1021C-->T) were assessed. RESULTS: VAS self-ratings showed significant or trend-level interactions of genotype and time during each session (p = .004, .09 and .003, respectively) with TT homozygotes endorsing greater paranoia over time than either CT or CC individuals. Interactions were significant at all doses in African Americans (n = 19; p = .02, .04 and .05). No other demographic or experimental variable distinguished genotypic groups. CONCLUSIONS: Results indicate that individuals homozygous for the 'very low-activity' T allele at DbetaH -1021C-->T show an increased propensity to paranoia over time during cocaine self-administration.
Authors: Rasmon Kalayasiri; Joel Gelernter; Lindsay Farrer; Roger Weiss; Kathleen Brady; Ralitza Gueorguieva; Henry R Kranzler; Robert T Malison Journal: Drug Alcohol Depend Date: 2009-11-26 Impact factor: 4.492
Authors: D Matuskey; B Pittman; J I Chen; J Wanyiri; H Nadim; P Jatlow; R Gueorguieva; M N Potenza; P T Morgan; Z Bhagwagar; R T Malison Journal: Pharmacol Biochem Behav Date: 2012-11 Impact factor: 3.533
Authors: Rasmon Kalayasiri; Viroj Verachai; Joel Gelernter; Apiwat Mutirangura; Robert T Malison Journal: Addiction Date: 2014-03-17 Impact factor: 6.526
Authors: Gustavo A Angarita; Brian Pittman; Ralitza Gueorguieva; Rasmon Kalayasiri; Wendy J Lynch; Atapol Sughondhabirom; Peter T Morgan; Robert T Malison Journal: Pharmacol Biochem Behav Date: 2009-12-21 Impact factor: 3.533