| Literature DB >> 17157217 |
Jorge Gómez-Mateo1, Luis Marin, María R López-Alvarez, M Rosa Moya-Quiles, Manuel Miras, Isabel Marin-Moreno, Carmen Botella, Pascual Parrilla, María R Alvarez-López, Manuel Muro.
Abstract
Cytokines are known to be important mediators during liver graft outcome and their gene polymorphism could affect the overall expression and secretion of cytokines. In this retrospective study, we analyzed the effect of TGF-beta1 polymorphism in 150 liver allograft recipients. Genotyping PCR-SSP were performed for TGF-beta1 gene (codon 10T/C and 25C/G). TGF-beta1 polymorphism at codon 10 and 25 correlate borderline with liver graft acceptance and when the combination between codon 10 and 25 was analyzed, it revealed that T/T G/C genotype and the TC haplotype were significantly associated with graft acceptance (p<0.05). TGF-beta1 high secretor phenotype was also increased in the acute rejection group close to significance (p=0.06). In conclusion, these findings show a correlation between TGF-beta1 gene polymorphism and liver graft acceptance.Entities:
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Year: 2006 PMID： 17157217 DOI： 10.1016/j.trim.2006.09.011
Source DB: PubMed Journal: Transpl Immunol ISSN： 0966-3274 Impact factor: 1.708