| Literature DB >> 17156894 |
Fernanda Gambogi Braga1, Elaine Soares Coimbra, Magnum de Oliveira Matos, Arturene Maria Lino Carmo, Marisa Damato Cancio, Adilson David da Silva.
Abstract
We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3'-chloropropylthio)purine 2 [11,12] [corrected] 6-(3'-(thioethylamine)propylthio)purine 5, 6-(alpha-aceticacidthio)purine 7 and 6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine 14 with an IC(50)=50, 50, 39 and 29 microM, respectively.Entities:
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Year: 2006 PMID： 17156894 DOI： 10.1016/j.ejmech.2006.10.014
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514