Literature DB >> 17154496

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.

Jang-Yang Chang1, Hsing-Pang Hsieh, Chi-Yen Chang, Kuo-Shun Hsu, Yi-Fang Chiang, Chi-Ming Chen, Ching-Chuan Kuo, Jing-Ping Liou.   

Abstract

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC50 values of 1.1 and 1.2 microM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17154496     DOI： 10.1021/jm061076u

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  11 in total

Review 1.  Fragment-based QSAR: perspectives in drug design.

Authors:  Lívia B Salum; Adriano D Andricopulo
Journal:  Mol Divers       Date:  2009-01-31       Impact factor: 2.943

2.  Linobiflavonoid inhibits human lung adenocarcinoma A549 cells: effect on tubulin protein.

Authors:  Dongbo Zhao; Guang Yang; Qingyang Meng; Junxing Liu; Shuang Yang
Journal:  Mol Biol Rep       Date:  2013-09-23       Impact factor: 2.316

Review 3.  An overview of tubulin inhibitors that interact with the colchicine binding site.

Authors:  Yan Lu; Jianjun Chen; Min Xiao; Wei Li; Duane D Miller
Journal:  Pharm Res       Date:  2012-07-20       Impact factor: 4.200

4.  Inhibitory action of chamaejasmin A against human HEP-2 epithelial cells: effect on tubulin protein.

Authors:  Yan Zhao; Fenglian Wu; Yu Wang; Shengwu Chen; Guojun Han; Ming Liu; Dejun Jin
Journal:  Mol Biol Rep       Date:  2012-10-07       Impact factor: 2.316

5.  Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking.

Authors:  Miao-Miao Niu; Jing-Yi Qin; Cai-Ping Tian; Xia-Fei Yan; Feng-Gong Dong; Zheng-Qi Cheng; Guissi Fida; Man Yang; Hai-Yan Chen; Yue-Qing Gu
Journal:  Acta Pharmacol Sin       Date:  2014-06-09       Impact factor: 6.150

Review 6.  Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018-2021).

Authors:  Ashima Dhiman; Rupam Sharma; Rajesh K Singh
Journal:  Acta Pharm Sin B       Date:  2022-04-01       Impact factor: 14.903

7.  Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin.

Authors:  Alba Agudo-López; Elena Prieto-García; José Alemán; Carlos Pérez; C Vanesa Díaz-García; Lucía Parrilla-Rubio; Silvia Cabrera; Carmen Navarro-Ranninger; Hernán Cortés-Funes; José A López-Martín; M Teresa Agulló-Ortuño
Journal:  Mol Cancer       Date:  2017-02-23       Impact factor: 27.401

8.  Synthesis, biological evaluation and molecular docking investigation of new sulphonamide derivatives bearing naphthalene moiety as potent tubulin polymerisation inhibitors.

Authors:  Guangcheng Wang; Meiyan Fan; Wenjing Liu; Min He; Yongjun Li; Zhiyun Peng
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051

9.  Anticancer activity of MPT0E028, a novel potent histone deacetylase inhibitor, in human colorectal cancer HCT116 cells in vitro and in vivo.

Authors:  Han-Li Huang; Han-Lin Huang; Hsueh-Yun Lee; An-Chi Tsai; Chieh-Yu Peng; Mei-Jung Lai; Jing-Chi Wang; Shiow-Lin Pan; Che-Ming Teng; Jing-Ping Liou
Journal:  PLoS One       Date:  2012-08-22       Impact factor: 3.240

10.  Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3'-O-substituted carbonic ether moiety as potential antitumor agents.

Authors:  Mingyi Ma; Longru Sun; Hongxiang Lou; Mei Ji
Journal:  Chem Cent J       Date:  2013-12-05       Impact factor: 4.215
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.