Literature DB >> 1715287

N-deglycosylation and immunological identification indicates the existence of beta-subunit isoforms of the rat GABAA receptor.

A Buchstaller1, D Adamiker, K Fuchs, W Sieghart.   

Abstract

beta 2- and beta 3-subunits of GABAA receptors purified from the brains of 5-10-day-old rats were investigated in the intact or completely N-deglycosylated state using the beta-subunit-specific monoclonal antibody bd-17 and polyclonal antibodies directed against synthetic amino acid sequences specific for the GABAA receptor beta 2- or beta 3-subunits. The present results seem to indicate the existence of two different isoforms of the beta 3-subunit and several different isoforms of the beta 2-subunit of the GABAA receptor which probably are produced by alternative splicing.

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Year:  1991        PMID： 1715287     DOI： 10.1016/0014-5793(91)80008-q

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  3 in total

1.  Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

Authors:  K L Hadingham; P C Harkness; R M McKernan; K Quirk; B Le Bourdellès; A L Horne; J A Kemp; E A Barnard; C I Ragan; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

Review 2.  Brain GABAA receptors studied with subunit-specific antibodies.

Authors:  A L De Blas
Journal:  Mol Neurobiol       Date:  1996-02       Impact factor: 5.590

3.  N-Glycosylation of GABAA receptor subunits is altered in Schizophrenia.

Authors:  Toni Marie Mueller; Vahram Haroutunian; James H Meador-Woodruff
Journal:  Neuropsychopharmacology       Date:  2013-08-06       Impact factor: 7.853
  3 in total

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