Paweł K Burduk1. 1. Katedra i Klinika Otolaryngologii CM im. L. Rydygiera w Bydgoszczy UMK w Toruniu. pburduk@wp.pl
Abstract
INTRODUCTION: Helicobacter pylori causes different chronic infections that has been linked to the development of malignant disease of the aerodigestive tract. The larynx as a part of upper aerodigestive tract could be infected with this bacteria, mostly by gastroesophageal reflux. MATERIAL AND METHODS: In our study rapid urease tests were performed on the tissue samples of 80 patients with laryngeal squamous cell carcinoma and 34 control with benign laryngeal pathology. RESULTS: In the evaluation of 80 specimens with laryngeal cancer in 62.5% we recorded a positive urease test reaction pointing for coexisting Helicobacter pylori infection and in 37.8% of cases the negative reaction. In the control group a positive reaction was in 47.3% of cases and negative in 52.7% of cases. CONCLUSIONS: Inflammation inducted by Helicobacter pylori would cause epithelial cell proliferation and could follow to development of laryngeal cancer. Thus, laryngeal tissue can be colonized by some other agents containing a urease enzyme other than Helicobacter pylori an additional tests may be performed. In our future investigation we are trying to estimate the Helicobacter pylori infection in pathologic tissue using a polymerase chain reaction (PCR).
INTRODUCTION:Helicobacter pylori causes different chronic infections that has been linked to the development of malignant disease of the aerodigestive tract. The larynx as a part of upper aerodigestive tract could be infected with this bacteria, mostly by gastroesophageal reflux. MATERIAL AND METHODS: In our study rapid urease tests were performed on the tissue samples of 80 patients with laryngeal squamous cell carcinoma and 34 control with benign laryngeal pathology. RESULTS: In the evaluation of 80 specimens with laryngeal cancer in 62.5% we recorded a positive urease test reaction pointing for coexisting Helicobacter pyloriinfection and in 37.8% of cases the negative reaction. In the control group a positive reaction was in 47.3% of cases and negative in 52.7% of cases. CONCLUSIONS: Inflammation inducted by Helicobacter pylori would cause epithelial cell proliferation and could follow to development of laryngeal cancer. Thus, laryngeal tissue can be colonized by some other agents containing a urease enzyme other than Helicobacter pylori an additional tests may be performed. In our future investigation we are trying to estimate the Helicobacter pyloriinfection in pathologic tissue using a polymerase chain reaction (PCR).