Hong-lan Li1, Yu-tang Gao, Qi Li, Da-ke Liu. 1. Cancer Institute of Shanghai Jiaotong Univercity and Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.
Abstract
OBJECTIVE: To investigate the association between anthropometry and risk of breast cancer among pre-and post-menopausal women in urban Shanghai. METHODS: A total of 73 461 female residents aged 40 to 70 years in urban Shanghai were recruited in a prospective cohort study (the Shanghai women's health study) during 1997 through 2000, and were actively followed up biennially. During mean follow-up period of 5.66 years, 432 incident cases of breast cancer were identified in the cohort. Cox regression model was used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for some potential confounding factors, baseline weight, body mass index(BMI), waist-to-hip ratio(WHR) and weight gain since age 20 were positively associated with the increased risk of breast cancer among postmenopausal women. The positive association between height and breast cancer was found among premenopausal women. Among them, those with height taller than 161 cm at age 20 experienced 1.84 fold increased risk (95% CI: 1.30-2.61) of breast cancer compared to their counterpart with height shorter than 157.1 cm. Women who were either much heavier or lighter than average at age 20 were at reduced risk. Further analyses mutually adjusted for BMI and WHR did not substantially alter the positive association for both BMI and WHR. After further adjustment for BMI, weight gain since age 20 was significantly associated to an increased risk for postmenopausal breast cancer (RR = 1.61, 95% CI: 1.09-2.37). CONCLUSIONS: Weight gain and central obesity seemed to be strong predictors for the risk of breast cancer among postmenopausal women. Controlling weight and decreasing fat around waist were effective means to prevent postmenopausal breast cancer and height might serve as a risk factor for premenopausal breast cancer.
OBJECTIVE: To investigate the association between anthropometry and risk of breast cancer among pre-and post-menopausal women in urban Shanghai. METHODS: A total of 73 461 female residents aged 40 to 70 years in urban Shanghai were recruited in a prospective cohort study (the Shanghai women's health study) during 1997 through 2000, and were actively followed up biennially. During mean follow-up period of 5.66 years, 432 incident cases of breast cancer were identified in the cohort. Cox regression model was used to estimate the adjusted relative risks (RRs) and 95% confidence intervals (CIs). RESULTS: After adjustment for some potential confounding factors, baseline weight, body mass index(BMI), waist-to-hip ratio(WHR) and weight gain since age 20 were positively associated with the increased risk of breast cancer among postmenopausal women. The positive association between height and breast cancer was found among premenopausal women. Among them, those with height taller than 161 cm at age 20 experienced 1.84 fold increased risk (95% CI: 1.30-2.61) of breast cancer compared to their counterpart with height shorter than 157.1 cm. Women who were either much heavier or lighter than average at age 20 were at reduced risk. Further analyses mutually adjusted for BMI and WHR did not substantially alter the positive association for both BMI and WHR. After further adjustment for BMI, weight gain since age 20 was significantly associated to an increased risk for postmenopausal breast cancer (RR = 1.61, 95% CI: 1.09-2.37). CONCLUSIONS:Weight gain and central obesity seemed to be strong predictors for the risk of breast cancer among postmenopausal women. Controlling weight and decreasing fat around waist were effective means to prevent postmenopausal breast cancer and height might serve as a risk factor for premenopausal breast cancer.
Authors: Minouk J Schoemaker; Hazel B Nichols; Lauren B Wright; Mark N Brook; Michael E Jones; Katie M O'Brien; Hans-Olov Adami; Laura Baglietto; Leslie Bernstein; Kimberly A Bertrand; Marie-Christine Boutron-Ruault; Yu Chen; Avonne E Connor; Laure Dossus; A Heather Eliassen; Graham G Giles; Inger T Gram; Susan E Hankinson; Rudolf Kaaks; Timothy J Key; Victoria A Kirsh; Cari M Kitahara; Susanna C Larsson; Martha Linet; Huiyan Ma; Roger L Milne; Kotaro Ozasa; Julie R Palmer; Elio Riboli; Thomas E Rohan; Carlotta Sacerdote; Atsuko Sadakane; Malin Sund; Rulla M Tamimi; Antonia Trichopoulou; Giske Ursin; Kala Visvanathan; Elisabete Weiderpass; Walter C Willett; Alicja Wolk; Anne Zeleniuch-Jacquotte; Dale P Sandler; Anthony J Swerdlow Journal: Int J Cancer Date: 2020-02-15 Impact factor: 7.316