Literature DB >> 17152378

Ultrastructural characteristics of type A epithelioid cells during BCG-granulomatosis and treatment with lysosomotropic isoniazid.

V A Shkurupii1, M A Kozyaev, A P Nadeev.   

Abstract

We studied BCG-granulomas, their cellular composition, and ultrastructure of type A epithelioid cells in the liver of male BALB/c mice with spontaneous granulomatous inflammation. The animals received free isoniazid or isoniazid conjugated with lysosomotropic intracellularly prolonged matrix (dialdehyde dextran, molecular weight 65-75 kDa). Lysosomotropic isoniazid was accumulated in the vacuolar apparatus of epithelioid cells and produced a stimulatory effect on plastic processes in these cells.

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Year:  2006        PMID： 17152378     DOI： 10.1007/s10517-006-0206-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Destructive Processes and Fibrotic Complications in the Liver of Mice with BSG-Induced Granulomatosis Treated with Anti-Tuberculous Drugs.

Authors:  V A Shkurupy; A M Sinyavskaya; A V Troitskii
Journal:  Bull Exp Biol Med       Date:  2021-03-13       Impact factor: 0.804

2.  In Vitro Study of the Expression of CD1, CD14, CD25, CD30, CD35, CD95 Receptors by Macrophages of Mice Infected with Mycobacterium tuberculosis.

Authors:  D A Il'in; V A Shkurupy; E S Akhramenko
Journal:  Bull Exp Biol Med       Date:  2021-11-19       Impact factor: 0.804

3.  The Study of Efficiency of the Approach to Prevent the Adhesions in the Abdominal Cavity of Rats.

Authors:  M A Karpov; V A Shkurupy; A V Troitskii
Journal:  Bull Exp Biol Med       Date:  2021-09-20       Impact factor: 0.804
  3 in total

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