| Literature DB >> 17151803 |
Akira Tari1, Yasuhiko Kitadai, Masaharu Sumii, Atsunori Sasaki, Hiroshi Tani, Sinji Tanaka, Kazuaki Chayama.
Abstract
Helicobacter pylori infection induces chronic gastritis and lowers gastric juice ascorbic acid concentrations. We investigated how H. pylori eradication affected multiple variables that could prevent or delay development of new or occult gastric cancer in patients with early gastric cancer treated by endoscopic mucosal resection. Gastric juice pH, nitrite concentrations, and total vitamin C concentrations, serum concentrations of vitamin C and specific H. pylori antibody, and intensity of neutrophil infiltration in gastric mucosa were determined before and after successful H. pylori eradication. Successful eradication increased acid output and ascorbic acid secretion into gastric juice, accompanied by disappearance of polymorphonuclear infiltration from the surface epithelium and decreased gastric juice nitrite concentrations. Our data suggest that H. pylori eradication decreases the nitrosation rate as the ratio of vitamin C to nitrite increases. This decreases reactive oxygen species and nitric oxide, eliminating their damaging effect on DNA and reducing cell turnover.Entities:
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Year: 2006 PMID： 17151803 DOI： 10.1007/s10620-006-9411-y
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.487