Literature DB >> 17150843

Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase.

Masahiro Ikejiri1, Masayuki Saijo, Shigeru Morikawa, Shuetsu Fukushi, Tetsuya Mizutani, Ichiro Kurane, Tokumi Maruyama.   

Abstract

Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.

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Year:  2006        PMID: 17150843     DOI: 10.1093/nass/nrl056

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser (Oxf)        ISSN: 0261-3166


  1 in total

1.  Deoxygenation of 5-O-benzoyl-1,2-isopropylidene-3-O-imidazolylthiocarbonyl-α-d-xylofuranose using dimethyl phosphite: an efficient alternate method towards a 3'-deoxynucleoside glycosyl donor.

Authors:  Ivan Zlatev; Jean-Jacques Vasseur; François Morvan
Journal:  Tetrahedron Lett       Date:  2008-03-21       Impact factor: 2.415

  1 in total

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