Literature DB >> 17150777

Rational installation of an allosteric effector on a designed ribozyme.

Shohei Kuramitsu1, Yoshiya Ikawa, Tan Inoue.   

Abstract

We designed and constructed an allosterically controllable ribozyme with rational molecular design. An allosteric modular unit that is under the control of an organic molecule was installed to an artificially designed ribozyme on the basis of the fact that the RNA is an assemblage of functional modular units. The ribozyme was successfully converted to allosterically controllable form.

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Year:  2005        PMID: 17150777     DOI: 10.1093/nass/49.1.349

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser (Oxf)        ISSN: 0261-3166


  2 in total

1.  Rational optimization of the DSL ligase ribozyme with GNRA/receptor interacting modules.

Authors:  Junya Ishikawa; Shigeyoshi Matsumura; Luc Jaeger; Tan Inoue; Hiroyuki Furuta; Yoshiya Ikawa
Journal:  Arch Biochem Biophys       Date:  2009-09-01       Impact factor: 4.013

Review 2.  Generation and development of RNA ligase ribozymes with modular architecture through "design and selection".

Authors:  Yuki Fujita; Junya Ishikawa; Hiroyuki Furuta; Yoshiya Ikawa
Journal:  Molecules       Date:  2010-08-26       Impact factor: 4.411

  2 in total

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