OBJECTIVE: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs). STUDY DESIGN: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry. RESULTS: In normal oral mucosa, linear deposits of these proteins were found at the epithelial-mesenchymal junction, but not in epithelial cytoplasm. In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types. For CCOTs, laminin 5 was found faintly in suprabasal cells, but expressed strongly in ghost cells. For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization. CONCLUSIONS: Laminin 1 may be a marker for odontogenic epithelium. Additionally, laminin 5 may be involved in ghost cell formation and initiation of calcification.
OBJECTIVE: The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs). STUDY DESIGN: BMCs were analyzed in 14 ameloblastomas, 7 CCOTs, and 7 AOTs using immunohistochemistry. RESULTS: In normal oral mucosa, linear deposits of these proteins were found at the epithelial-mesenchymal junction, but not in epithelial cytoplasm. In all tumors studied, linear deposits of all proteins were found at the epithelial-mesenchymal junction; laminin 1 was expressed in all tumor cells, regardless of cell types. For CCOTs, laminin 5 was found faintly in suprabasal cells, but expressed strongly in ghost cells. For AOTs, laminin 5 strongly decorated tumor cells adjacent to mineralization. CONCLUSIONS: Laminin 1 may be a marker for odontogenic epithelium. Additionally, laminin 5 may be involved in ghost cell formation and initiation of calcification.
Authors: Ana Miryam Costa de Medeiros; Cassiano Francisco Weege Nonaka; Hébel Cavalcanti Galvão; Lélia Batista de Souza; Roseana de Almeida Freitas Journal: Eur Arch Otorhinolaryngol Date: 2009-05-23 Impact factor: 2.503
Authors: Haleh Davanian; Anangi Balasiddaiah; Robert Heymann; Magnus Sundström; Poppy Redenström; Mikael Silfverberg; David Brodin; Matti Sällberg; Sven Lindskog; Carina Kruger Weiner; Margaret Chen Journal: Oncotarget Date: 2017-01-17