| Literature DB >> 17150338 |
Enrico Cancellotti1, Rona M Barron, Matthew T Bishop, Patricia Hart, Frances Wiseman, Jean C Manson.
Abstract
PrP has a central role in the Transmissible Spongiform Encephalopathies (TSEs), and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent. However, precisely how host PrP influences the outcome of disease has not been established. To investigate this we have produced by gene targeting a series of inbred lines of transgenic mice expressing different PrP genes. This allows us to study directly the influence of the host PrP gene in TSEs. We have examined the role of glycosylation, point mutations, polymorphisms and PrP from different species on host susceptibility and the disease process both within the murine species and across species barriers.Entities:
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Year: 2006 PMID： 17150338 DOI： 10.1016/j.bbadis.2006.10.013
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002