OBJECTIVE: This pilot study investigated whether our previous findings of disrupted normal sexual brain dimorphisms in language-associated regions in schizophrenia were linked with our previously reported sex differences in language dysfunction in schizophrenia. METHOD: Nineteen adults with schizophrenia and 15 normal comparisons were tested on phonology, semantics and grammar and underwent structural MRI. RESULTS: Among males, left hippocampal and left planum temporale (PT) abnormalities were associated with phonological, semantic and grammar deficits, accounting for 17-52% and 27-33%, respectively, of variance in diagnostic group differences. Anterior cingulate gyrus was significantly associated with semantics. Among females, right Heschl's Gyrus (HG) and left PT were significantly associated with phonology, right HG with semantics and grammar and right hippocampus with semantics. CONCLUSIONS: These preliminary findings suggest disrupted sexual brain dimorphisms in schizophrenia are associated with sex-specific language deficits, and left hippocampal abnormalities, in particular, contribute to language dysfunction among men. Abnormalities in right cortical temporal regions showed stronger associations with language dysfunction among females.
OBJECTIVE: This pilot study investigated whether our previous findings of disrupted normal sexual brain dimorphisms in language-associated regions in schizophrenia were linked with our previously reported sex differences in language dysfunction in schizophrenia. METHOD: Nineteen adults with schizophrenia and 15 normal comparisons were tested on phonology, semantics and grammar and underwent structural MRI. RESULTS: Among males, left hippocampal and left planum temporale (PT) abnormalities were associated with phonological, semantic and grammar deficits, accounting for 17-52% and 27-33%, respectively, of variance in diagnostic group differences. Anterior cingulate gyrus was significantly associated with semantics. Among females, right Heschl's Gyrus (HG) and left PT were significantly associated with phonology, right HG with semantics and grammar and right hippocampus with semantics. CONCLUSIONS: These preliminary findings suggest disrupted sexual brain dimorphisms in schizophrenia are associated with sex-specific language deficits, and left hippocampal abnormalities, in particular, contribute to language dysfunction among men. Abnormalities in right cortical temporal regions showed stronger associations with language dysfunction among females.
Authors: L C Baxter; A J Saykin; L A Flashman; S C Johnson; S J Guerin; D R Babcock; H A Wishart Journal: Brain Lang Date: 2003-02 Impact factor: 2.381
Authors: L J Seidman; S V Faraone; J M Goldstein; J M Goodman; W S Kremen; R Toomey; J Tourville; D Kennedy; N Makris; V S Caviness; M T Tsuang Journal: Biol Psychiatry Date: 1999-10-01 Impact factor: 13.382
Authors: S L Rauch; H Kim; N Makris; G R Cosgrove; E H Cassem; C R Savage; B H Price; A A Nierenberg; D Shera; L Baer; B Buchbinder; V S Caviness; M A Jenike; D N Kennedy Journal: J Neurosurg Date: 2000-12 Impact factor: 5.115
Authors: Nikolaos Koutsouleris; Christian Gaser; Katja Patschurek-Kliche; Johanna Scheuerecker; Ronald Bottlender; Petra Decker; Gisela Schmitt; Maximilian Reiser; Hans-Jürgen Möller; Eva M Meisenzahl Journal: Hum Brain Mapp Date: 2011-08-30 Impact factor: 5.038
Authors: Alan N Francis; Larry J Seidman; Gul A Jabbar; Raquelle Mesholam-Gately; Heidi W Thermenos; Richard Juelich; Ashley C Proal; Martha Shenton; Marek Kubicki; Ian Mathew; Matcheri Keshavan; Lynn E Delisi Journal: Schizophr Res Date: 2012-08-11 Impact factor: 4.939
Authors: Christine A Carroll; Jennifer Boggs; Brian F O'Donnell; Anantha Shekhar; William P Hetrick Journal: Brain Cogn Date: 2008-02-11 Impact factor: 2.310