Literature DB >> 17149695

Pituitary tumor transforming gene: an important gene in normal cellular functions and tumorigenesis.

C Bradshaw1, S S Kakar.   

Abstract

Pituitary tumor transforming gene (PTTG) is an oncogene which is found to be highly expressed in proliferating cells and in most of the tumors analyzed to date. Overexpression of PTTG induces cellular transformation and promotes tumor development in nude mice. PTTG is regulated by various growth factors including insulin and IGF-1. PTTG is a multifunctional and multidomain protein. Some of the functions of PTTG include inhibition of separation of sister chromatids, expression and secretion of angiogenic and metastatic factors. In this review we focus on expression of PTTG in normal and tumor tissues, define its biological function, its role in tumorigenesis, and its interaction with other proteins that may play important role in mediating tumorigenic function of PTTG.

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Year:  2007        PMID： 17149695     DOI： 10.14670/HH-22.219

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  10 in total

1.  Expression of pituitary tumor-transforming 2 in human glioblastoma cell lines and its role in glioblastoma tumorigenesis.

Authors:  Yunbao Guo; Yimeng Shao; Jing Chen; Songbai Xu; Xingdong Zhang; Haiyan Liu
Journal:  Exp Ther Med       Date:  2016-03-15       Impact factor: 2.447

2.  Expression of cell cycle regulators and biomarkers of proliferation and regrowth in human pituitary adenomas.

Authors:  Mark Gruppetta; Robert Formosa; Sharon Falzon; Sabrina Ariff Scicluna; Edward Falzon; James Degeatano; Josanne Vassallo
Journal:  Pituitary       Date:  2017-06       Impact factor: 4.107

3.  Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma.

Authors:  Tetsuo Ito; Yutaka Shimada; Takatsugu Kan; Stefan David; Yulan Cheng; Yuriko Mori; Rachana Agarwal; Bogdan Paun; Zhe Jin; Alexandru Olaru; James P Hamilton; Jian Yang; John M Abraham; Stephen J Meltzer; Fumiaki Sato
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

4.  Expression of pituitary tumor transforming gene (PTTG) in human pituitary macroadenomas.

Authors:  Wang Jia; Runchun Lu; Guijun Jia; Ming Ni; Zhiqing Xu
Journal:  Tumour Biol       Date:  2013-02-13

Review 5.  What can we learn from rodents about prolactin in humans?

Authors:  Nira Ben-Jonathan; Christopher R LaPensee; Elizabeth W LaPensee
Journal:  Endocr Rev       Date:  2007-12-05       Impact factor: 19.871

6.  Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma.

Authors:  Yuanyuan Wang; Wenqiao Zang; Yuwen Du; Yunyun Ma; Min Li; Ping Li; Xudong Chen; Tao Wang; Ziming Dong; Guoqiang Zhao
Journal:  J Transl Med       Date:  2013-12-06       Impact factor: 5.531

7.  Cloning of Porcine Pituitary Tumor Transforming Gene 1 and Its Expression in Porcine Oocytes and Embryos.

Authors:  Bingkun Xie; Zhaoxian Qin; Shuai Liu; Suqun Nong; Qingyan Ma; Baojian Chen; Mingjun Liu; Tianbiao Pan; D Joshua Liao
Journal:  PLoS One       Date:  2016-04-08       Impact factor: 3.240

8.  PTTG3P promotes gastric tumour cell proliferation and invasion and is an indicator of poor prognosis.

Authors:  Weiwei Weng; Shujuan Ni; Yiqin Wang; Midie Xu; Qiongyan Zhang; Yusi Yang; Yong Wu; Qinghua Xu; Peng Qi; Cong Tan; Dan Huang; Ping Wei; Zhaohui Huang; Yuqing Ma; Wei Zhang; Weiqi Sheng; Xiang Du
Journal:  J Cell Mol Med       Date:  2017-06-19       Impact factor: 5.310

9.  Expression of Serum PTTG1 in Laryngeal Carcinoma and Its Correlation to Prognosis.

Authors:  Kunpeng Ma; Xiuxia Sun; Limin Ma; Shenglin Zhang
Journal:  Clin Exp Otorhinolaryngol       Date:  2019-08-27       Impact factor: 3.372

10.  Securin promotes the identification of favourable outcome in invasive breast cancer.

Authors:  K Talvinen; H Karra; S Hurme; M Nykänen; A Nieminen; J Anttinen; T Kuopio; P Kronqvist
Journal:  Br J Cancer       Date:  2009-08-18       Impact factor: 7.640
  10 in total

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