BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend <0.0001), duration of exposure (1.73; 1.26-2.39; P for trend = 0.0001) and weighted duration of exposure (1.88; 1.35-2.61; P for trend <0.0001). We did not observe any interaction beyond a multiplicative model between tobacco smoking and silica exposure. CONCLUSIONS: Our results support the hypothesis that silica is an important risk factor for lung cancer. This risk could not be explained by exposure to other occupational carcinogens or smoking, and it was present for the main histologic types of lung cancer, different sources of silica exposure, and different industrial settings.
BACKGROUND: The role of crystalline silica dust as a possible cause of lung cancer has been controversial. Relatively few large community-based studies have been conducted to investigate the lung cancer risk from exposure to silica at low levels, taking into account potential confounding factors. METHODS: Detailed lifestyle and occupational information were collected from 2852 newly diagnosed cases of lung cancer and 3104 controls between 1998 and 2002 in 7 European countries. For each job held, local experts assessed the probability, intensity, and duration of silica exposure. RESULTS: Occupational exposure to crystalline silica was associated with an increased risk of lung cancer (odds ratio = 1.37; 95% confidence interval = 1.14-1.65). This risk was most apparent for the upper tertile of cumulative exposure (OR = 2.08; 95% CI = 1.49-2.90; P for trend <0.0001), duration of exposure (1.73; 1.26-2.39; P for trend = 0.0001) and weighted duration of exposure (1.88; 1.35-2.61; P for trend <0.0001). We did not observe any interaction beyond a multiplicative model between tobacco smoking and silica exposure. CONCLUSIONS: Our results support the hypothesis that silica is an important risk factor for lung cancer. This risk could not be explained by exposure to other occupational carcinogens or smoking, and it was present for the main histologic types of lung cancer, different sources of silica exposure, and different industrial settings.
Authors: Sara De Matteis; Dario Consonni; Jay H Lubin; Margaret Tucker; Susan Peters; Roel Ch Vermeulen; Hans Kromhout; Pier Alberto Bertazzi; Neil E Caporaso; Angela C Pesatori; Sholom Wacholder; Maria Teresa Landi Journal: Int J Epidemiol Date: 2012-03-31 Impact factor: 7.196
Authors: Darren R Brenner; Paolo Boffetta; Eric J Duell; Heike Bickeböller; Albert Rosenberger; Valerie McCormack; Joshua E Muscat; Ping Yang; H-Erich Wichmann; Irene Brueske-Hohlfeld; Ann G Schwartz; Michele L Cote; Anne Tjønneland; Søren Friis; Loic Le Marchand; Zuo-Feng Zhang; Hal Morgenstern; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Lenka Foretova; Vladimir Janout; Vladimir Bencko; Miriam Schejbalova; Paul Brennan; Ioan N Mates; Philip Lazarus; John K Field; Olaide Raji; John R McLaughlin; Geoffrey Liu; John Wiencke; Monica Neri; Donatella Ugolini; Angeline S Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J Park; Rayjean J Hung Journal: Am J Epidemiol Date: 2012-09-17 Impact factor: 4.897
Authors: Calvin Ge; Susan Peters; Ann Olsson; Lützen Portengen; Joachim Schüz; Josué Almansa; Thomas Behrens; Beate Pesch; Benjamin Kendzia; Wolfgang Ahrens; Vladimir Bencko; Simone Benhamou; Paolo Boffetta; Bas Bueno-de-Mesquita; Neil Caporaso; Dario Consonni; Paul Demers; Eleonóra Fabiánová; Guillermo Fernández-Tardón; John Field; Francesco Forastiere; Lenka Foretova; Pascal Guénel; Per Gustavsson; Vikki Ho; Vladimir Janout; Karl-Heinz Jöckel; Stefan Karrasch; Maria Teresa Landi; Jolanta Lissowska; Danièle Luce; Dana Mates; John McLaughlin; Franco Merletti; Dario Mirabelli; Nils Plato; Hermann Pohlabeln; Lorenzo Richiardi; Peter Rudnai; Jack Siemiatycki; Beata Świątkowska; Adonina Tardón; Heinz-Erich Wichmann; David Zaridze; Thomas Brüning; Kurt Straif; Hans Kromhout; Roel Vermeulen Journal: Am J Respir Crit Care Med Date: 2020-08-01 Impact factor: 21.405
Authors: Thomas C Erren; Christine B Glende; Peter Morfeld; Claus Piekarski Journal: Int Arch Occup Environ Health Date: 2008-12-06 Impact factor: 3.015
Authors: Timothy N Perkins; Arti Shukla; Paul M Peeters; Jeremy L Steinbacher; Christopher C Landry; Sherrill A Lathrop; Chad Steele; Niki L Reynaert; Emiel F M Wouters; Brooke T Mossman Journal: Part Fibre Toxicol Date: 2012-02-02 Impact factor: 9.400